Gingerol containing polymeric nanofibers: a healing touch for accelerated wound recovery.

OBJECTIVE

In the current research, 6-gingerol (GA)-loaded were developed, and their potential usage in wound healing was evaluated.

SIGNIFICANCE

This study investigates the effectiveness of nanofibrous membranes composed of sodium alginate (SA), poly(vinyl alcohol) (PVA), and 6-gingerol (GA) as delivery systems for anti-inflammatory agents in the context of wound dressings.

METHODS

GA-loaded SA/PVA nanofiber was prepared using electrospinning. characterization of this nanofiber included the examination of comprehensive characterization, anti-inflammatory and antioxidant activities, cytotoxicity, a scratch tes and skin test.

RESULTS

GA was extracted from , and its successful isolation was confirmed through analyses such as H-NMR, C-NMR. Then GA was electrospuned into the SA/PVA nanofibers, and scanning electron microscopy (SEM) imaging revealed that the fiber diameters of the formulations ranged between 148 nm and 176 nm. Anti-inflammatory and antioxidant studies demonstrated that the effectiveness of GA increased with higher doses; however, this increase was accompanied by decreased cell viability. In vitro release studies revealed that GA exhibited a burst release within the first 8 h, followed by a controlled release, reaching completion within 24 h. Within the scope of release kinetics, release data are mathematically compatible with the Weibull model with high correlation. The scratch test results indicated that TB2 (%1 GA) promoted epithelialization. Furthermore, it was determined that TB2 (%1 GA) did not cause any irritation.

CONCLUSIONS

As a result, TB2 shows promise as a formulation for wound dressings, offering potential benefits in the field of wound care.