Kirsten D, Schaedel H, Barthelmes H
Z Gesamte Inn Med. 1985 Nov 1;40(21):625-9.
By means of indicret immunofluorescence sera of 56 patients with pulmonary sarcoidosis of the x-ray stages I-III--among them 25 patients with additional heart involvement--were examined to detect heart antibodies. At all x-ray stages of pulmonary sarcoidosis muscle antibodies were identified. Patients who were treated with glucocorticosteroids showed more antibodies against heart musculature than those ones without therapy. By reason of the results of the indirect immunofluorescence no reliable differentiation was possible between a group with pulmonary sarcoidosis and a group with pulmonary sarcoidosis and additional heart involvement. Similar results could be obtained by use of both animal muscle antigen and human myocardiac antigen so that the use of human myocardiac tissue does not seem to be necessary in order to demonstrate antibodies in case of sarcoidosis. The frequency of the proof of antibodies against muscle antigen draws the attention to an early or systemic affection of the muscular system in sarcoidosis.
通过间接免疫荧光法，对56例X线分期为I - III期的肺结节病患者的血清进行检测，以检测心脏抗体，其中25例患者伴有心脏受累。在肺结节病的所有X线分期中均发现了肌肉抗体。接受糖皮质激素治疗的患者比未接受治疗的患者表现出更多针对心肌组织的抗体。根据间接免疫荧光法的结果，无法在单纯肺结节病组和伴有心脏受累的肺结节病组之间进行可靠区分。使用动物肌肉抗原和人心肌抗原均可获得类似结果，因此在结节病病例中，似乎没有必要使用人心肌组织来证明抗体的存在。针对肌肉抗原抗体检测的频率引起了人们对结节病中肌肉系统早期或全身性受累的关注。
