Zhang Xiangdong, Qin Tangqi, Zhang Donghang, Du Junwang
Department of Anesthesiology, First People's Hospital of Tianshui City, Tianshui, Gansu, China.
Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
PLoS One. 2024 Aug 8;19(8):e0308335. doi: 10.1371/journal.pone.0308335. eCollection 2024.
Transversus abdominis plane (TAP) blocks are commonly performed for postoperative analgesia in elective cesarean section. Ropivacaine is the most commonly used local anesthetic for TAP blocks. Currently, the concentration of ropivacaine for TAP blocks is various, and increasing number of randomized controlled trials (RCTs) have compared the effects of different concentration of ropivacaine for TAP blocks in cesarean section. This protocol of a systematic review and meta-analysis aims to identify the optimal concentration of ropivacaine for TAP blocks in elective cesarean section.
Databases including PubMed, Web of science, the Cochrane library, and EMBASE will be searched from their inception to May 1, 2024. RCTs that investigated the analgesia of different concentrations of ropivacaine for TAP blocks in elective cesarean section will be identified. The analgesia duration will be the primary outcome. Secondary outcomes will include the analgesics consumption over postoperative 24 hours, postoperative pain scores at rest and movement, and the incidence of adverse effects. RevMan 5.4 software will used for statistical analysis. The evidence quality of synthesized results will be evaluated by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
Ethical approval is not applicable. The results of this study will be published on completion.
PROSPERO registration number: CRD42024496907.
腹横肌平面（TAP）阻滞常用于择期剖宫产术后镇痛。罗哌卡因是TAP阻滞最常用的局部麻醉药。目前，TAP阻滞所用罗哌卡因的浓度各不相同，越来越多的随机对照试验（RCT）比较了不同浓度罗哌卡因用于剖宫产TAP阻滞的效果。本系统评价和荟萃分析方案旨在确定择期剖宫产TAP阻滞罗哌卡因的最佳浓度。
将检索包括PubMed、科学网、Cochrane图书馆和EMBASE在内的数据库，检索时间从建库至2024年5月1日。将纳入研究不同浓度罗哌卡因用于择期剖宫产TAP阻滞镇痛效果的RCT。镇痛持续时间将作为主要结局。次要结局将包括术后24小时内的镇痛药消耗量、静息和活动时的术后疼痛评分以及不良反应的发生率。将使用RevMan 5.4软件进行统计分析。将采用推荐分级评估、制定与评价（GRADE）方法评估综合结果的证据质量。
无需伦理批准。本研究结果将在完成后发表。
PROSPERO注册号：CRD42024496907。
