School of Medicine, Iran University of Medical Science, Tehran, Iran.
Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Pathol Res Pract. 2024 Sep;261:155510. doi: 10.1016/j.prp.2024.155510. Epub 2024 Jul 31.
Gliomas are among the most common cancers in the central nervous system, arising through various signaling pathways. One significant pathway is Wnt signaling, a tightly regulated process that plays a crucial role in gliomagenesis and development. The current study aims to explore the relationship between circular RNAs (circRNAs) and the Wnt/β-catenin signaling pathway in gliomas, considering the growing recognition of circRNAs in disease pathogenesis. A comprehensive review of recent research was conducted to investigate the roles of circRNAs in gliomas, focusing on their expression patterns and interactions with the Wnt signaling pathway. The analysis included studies examining circRNAs' function as microRNA sponges and their impact on glioma biology. The findings reveal that circRNAs are differentially expressed in gliomas and significantly influence the occurrence, growth, and metastasis of these tumors. Specifically, circRNAs interact with the Wnt signaling pathway, affecting glioma development and progression. This interaction highlights the importance of circRNAs in glioma pathophysiology. Understanding the regulatory network involving circRNAs and Wnt signaling offers valuable insights into glioma pathophysiology. CircRNAs hold promise as diagnostic and prognostic biomarkers and may serve as targets for novel therapeutic strategies in glioma treatment.
神经胶质瘤是中枢神经系统中最常见的癌症之一，它通过各种信号通路发生。一个重要的途径是 Wnt 信号通路，这是一个严格调控的过程，在神经胶质瘤的发生和发展中起着关键作用。本研究旨在探讨 circRNAs 与 Wnt/β-catenin 信号通路在神经胶质瘤中的关系，考虑到 circRNAs 在疾病发病机制中的作用日益受到重视。对最近的研究进行了全面综述，以探讨 circRNAs 在神经胶质瘤中的作用，重点关注它们的表达模式及其与 Wnt 信号通路的相互作用。该分析包括研究 circRNAs 作为 microRNA 海绵的功能及其对神经胶质瘤生物学的影响。研究结果表明，circRNAs 在神经胶质瘤中表达差异显著，并显著影响这些肿瘤的发生、生长和转移。具体来说，circRNAs 与 Wnt 信号通路相互作用，影响神经胶质瘤的发生和发展。这种相互作用突出了 circRNAs 在神经胶质瘤病理生理学中的重要性。了解涉及 circRNAs 和 Wnt 信号通路的调控网络为神经胶质瘤病理生理学提供了有价值的见解。circRNAs 有望成为诊断和预后生物标志物，并可能成为神经胶质瘤治疗新的治疗策略的靶点。
