α-突触核蛋白 PET 成像，离帕金森病及相关疾病的体内神经病理学又近了一步。
Alpha synuclein PET imaging, a step closer to in vivo neuropathology in Parkinson's disease and related disorders.
机构信息
HM CINAC, Hospital Puerta del Sur, Fundación Hospitales de Madrid, Madrid, Spain; CIBERNED, Instituto Carlos III, Madrid, Spain.
HM CINAC, Hospital Puerta del Sur, Fundación Hospitales de Madrid, Madrid, Spain; CIBERNED, Instituto Carlos III, Madrid, Spain.
出版信息
Neuron. 2024 Aug 7;112(15):2457-2458. doi: 10.1016/j.neuron.2024.07.001.
In this issue of Neuron, Endo et al. develop a PET tracer capable of detecting alpha-synuclein (ɑ-syn). With validation in animal models and humans, this tracer brings us closer to being able to monitor the synuclein aggregation process and associated pathological changes in Parkinson's disease (PD) and other synucleinopathies.
本期《神经元》杂志上，Endo 等人开发了一种正电子发射断层扫描（PET）示踪剂，能够检测α-突触核蛋白（ɑ-syn）。该示踪剂在动物模型和人类中得到了验证，使我们能够更接近监测帕金森病（PD）和其他突触核蛋白病中突触核蛋白聚集过程和相关病理变化。
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