Department of Drug and Health Sciences, University of Catania, 95125, Catania, Italy.
Department of Biomedical and Biotechnological Sciences, Section of Anatomy, Histology and Movement Sciences, University of Catania, 95100, Catania, Italy.
Exp Eye Res. 2024 Oct;247:110024. doi: 10.1016/j.exer.2024.110024. Epub 2024 Aug 6.
Diabetic retinopathy (DR) is a microvascular complication of diabetes characterized by neurovascular impairment of the retina. The dysregulation of the mitophagy process occurs before apoptotic cell death and the appearance of vascular damage. In particular, mitochondrial alterations happen during DR development, supporting the hypothesis that mitophagy is negatively correlated to disease progression. This process is mainly regulated by the PTEN-induced putative kinase protein 1 (PINK1)/Parkin pathway whose activation promotes mitophagy. In this review, we will summarize the evidence reported in the literature demonstrating the involvement of the PINK1/Parkin pathway in diabetic retinopathy-induced retinal degeneration.
糖尿病性视网膜病变（DR）是糖尿病的一种微血管并发症，其特征是视网膜的神经血管功能障碍。自噬过程的失调发生在细胞凋亡和血管损伤之前。特别是，在 DR 发展过程中会发生线粒体改变，这支持了自噬与疾病进展呈负相关的假说。该过程主要受 PTEN 诱导的假定激酶蛋白 1（PINK1）/Parkin 途径调控，其激活可促进自噬。在这篇综述中，我们将总结文献中报道的证据，证明 PINK1/Parkin 途径参与了糖尿病性视网膜病变引起的视网膜变性。
