Deoxygenative radical cross-coupling of C(sp)-O/C(sp)-H bonds promoted by hydrogen-bond interaction.

Building C(sp)-rich architectures using simple and readily available starting materials will greatly advance modern drug discovery. C(sp)-H and C(sp)-O bonds are commonly used to strategically disassemble and construct bioactive compounds, respectively. However, the direct cross coupling of these two chemical bonds to form C(sp)-C(sp) bonds is rarely explored in existing literature. Conventional methods for forming C(sp)-C(sp) bonds via radical-radical coupling pathways often suffer from poor selectivity, severely limiting their practicality in synthetic applications. In this study, we present a single electron transfer (SET) strategy that enables the cleavage of amine α-C - H bonds and heterobenzylic C - O bonds to form C(sp)-C(sp) bonds. Preliminary mechanistic studies reveal a hydrogen bond interaction between substrates and phosphoric acid facilitates the cross-coupling of two radicals with high chemoselectivity. This methodology provides an effective approach to a variety of aza-heterocyclic unnatural amino acids and bioactive molecules.