Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Department of Pediatrics, Wilhelmina Children's Hospital University Medical Center Utrecht, Utrecht, the Netherlands.
Bone Marrow Transplant. 2024 Nov;59(11):1499-1505. doi: 10.1038/s41409-024-02390-4. Epub 2024 Aug 8.
The trajectory of hematopoietic stem cell transplantation (HSCT) is often accompanied by physically disabling complications that impair physical performance of pediatric patients. However, knowledge about when impairments in physical performance arise and the factors contributing to these impairments is limited. Therefore, we conducted a retrospective analysis of physical performance 100 days post-HSCT in patients aged 3-18 years. Additionally, we aim to elucidate the relationship between pre- and post-HSCT physical performance and to unravel the impact of intensive HSCT procedures on post-HSCT physical performance. To explore associations between physical performance outcomes post-HSCT and covariates, linear regression models were estimated. Seventy-seven patients were included with a median age of 11.8 years (interquartile range: 5.9, 14.8). Patients had lower hip flexion muscle strength and appendicular skeletal muscle mass and a slower rising from the floor time 100 days post-HSCT compared to average values of the normal population. Pre-HSCT physical performance was positively associated with physical performance post-HSCT, independent of age, the cumulative glucocorticoids dosage administered and the total duration of hospitalization during the HSCT trajectory. This explorative study highlights the potential role of prehabilitation in enhancing physical performance of pediatric HSCT patients.
造血干细胞移植（HSCT）的过程常常伴随着身体残疾的并发症，这些并发症会损害儿科患者的身体表现。然而，对于身体表现何时出现障碍以及导致这些障碍的因素的了解是有限的。因此，我们对 3-18 岁患者在 HSCT 后 100 天的身体表现进行了回顾性分析。此外，我们旨在阐明 HSCT 前后身体表现之间的关系，并揭示密集的 HSCT 程序对 HSCT 后身体表现的影响。为了探讨 HSCT 后身体表现结果与协变量之间的关联，我们估计了线性回归模型。共纳入 77 例患者，中位年龄为 11.8 岁（四分位距：5.9，14.8）。与普通人群的平均值相比，患者在 HSCT 后 100 天时髋关节屈曲肌肉力量、四肢骨骼肌质量较低，从地板上起身的时间较慢。HSCT 过程中，HSCT 前的身体表现与身体表现呈正相关，独立于年龄、累积糖皮质激素剂量和住院总时间。这项探索性研究强调了预康复在增强儿科 HSCT 患者身体表现方面的潜在作用。
