Aventura Hospital, Aventura, FL, USA.
Nicklaus Children's Hospital, Miami, USA, FL.
Adv Exp Med Biol. 2024;1448:293-305. doi: 10.1007/978-3-031-59815-9_21.
Infections caused by parasites and fungi can trigger the cytokine storm syndrome (CSS). These infections causing CSS can occur together with acquired immunodeficiencies, lymphomas, the use of immunosuppressive medications, transplant recipients, cancer, autoinflammatory, and autoimmune diseases or less frequently in healthy individuals. Histoplasma, Leishmania, Plasmodium, and Toxoplasma are the most frequent organisms associated with a CSS. It is very important to determine a previous travel history when evaluating a patient with a CSS triggered by these organisms as this may be the clue to the causal agent. Even though CSS is treated with specific therapies, an effort to find the causal organism should be carried out since the treatment of the infectious organism may stop the CSS. Diagnosing a CSS in the presence of parasitic or fungal sepsis should also lead to the study of an altered cytotoxic or hemophagocytic response in the susceptible host.
寄生虫和真菌引起的感染可引发细胞因子风暴综合征 (CSS)。引起 CSS 的这些感染可与获得性免疫缺陷、淋巴瘤、免疫抑制药物的使用、移植受者、癌症、自身炎症和自身免疫性疾病同时发生，或较少见于健康个体。组织胞浆菌、利什曼原虫、疟原虫和弓形体是与 CSS 最相关的常见病原体。当评估由这些病原体引起的 CSS 患者时，确定先前的旅行史非常重要，因为这可能是导致病原体的线索。尽管 CSS 采用特定疗法进行治疗，但应努力寻找病原体，因为治疗感染病原体可能会阻止 CSS。在寄生虫或真菌性败血症存在的情况下诊断 CSS 也应导致研究易感宿主中细胞毒性或噬血细胞反应的改变。
