Kusne Yael, Christiansen Michael, Conley Christopher, Gea-Banacloche Juan, Sen Ayan
Department of Internal Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA.
Department of Neurology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Case Rep Crit Care. 2021 Jan 22;2021:6612710. doi: 10.1155/2021/6612710. eCollection 2021.
Hemophagocytic lymphohistiocytosis (HLH) was originally described in pediatric patients presenting with fever, hepatosplenomegaly, and blood cell abnormalities. Later, HLH was recognized to occur in adults, often associated with hematologic malignancies or serious infections.
Patients presenting with HLH are critically ill, and rapid diagnosis is key. In adults, the search for the trigger must begin promptly as time to diagnosis effects survival. The underlying trigger in our patients was Histoplasma capsulatum infection, which is rare in the southwestern United States. Prompt diagnosis led to recovery in one patient, while the other did not survive.
噬血细胞性淋巴组织细胞增生症（HLH）最初在出现发热、肝脾肿大和血细胞异常的儿科患者中被描述。后来，人们认识到HLH也发生于成人，常与血液系统恶性肿瘤或严重感染相关。
出现HLH的患者病情危急，快速诊断是关键。在成人中，由于诊断时间影响生存，必须迅速开始寻找诱因。我们患者的潜在诱因是荚膜组织胞浆菌感染，这在美国西南部很罕见。及时诊断使一名患者康复，而另一名患者未能存活。
