经口内镜下食管肌切开术(E-POEM):未来方向与展望。

Esophageal Per-Oral Endoscopic Myotomy (E-POEM): Future Directions and Perspectives.

机构信息

Division of Gastroenterology and Hepatology, University of Florida, Gainesville, FL, USA.

Center for Interventional Endoscopy, AdventHealth, Orlando, FL, USA.

出版信息

Curr Gastroenterol Rep. 2024 Oct;26(10):241-250. doi: 10.1007/s11894-024-00938-4. Epub 2024 Aug 8.

Abstract

PURPOSE OF REVIEW

POEM is a mature procedure endorsed by societal guidelines as a first line therapy for achalasia and spastic esophageal disorders. Nonetheless, several questions remain, including expanding indications for POEM, periprocedural evaluation and management, and the optimal POEM technique to enhance clinical success while mitigating risk for reflux.

RECENT FINDINGS

There is uncertainty regarding several technical aspects of the POEM myotomy; though aggregating evidence supports the use of real-time impedance planimetry to guide the myotomy. While post-POEM reflux remains a concerning long term sequela, there is an increasing focus on the potential role of endoscopic anti-reflux interventions. Lastly, with the widespread adoption of POEM, we continue to witness ongoing efforts to standardize post-procedural care and training in this procedure. POEM is no longer a novel but rather established procedure. Yet, this technique has continued to evolve, with the aim of optimizing treatment success while reducing adverse events and risk for post-procedural reflux.

摘要

目的综述

经社会指南认可,POEM 是治疗贲门失弛缓症和痉挛性食管疾病的成熟一线疗法。尽管如此,仍存在一些问题,包括 POEM 的扩展适应证、围手术期评估和管理,以及优化 POEM 技术以提高临床成功率,同时降低反流风险。

最近的发现

POEM 肌切开术的几个技术方面存在不确定性;尽管综合证据支持使用实时阻抗平面图引导肌切开术。虽然 POEM 术后反流仍然是一个令人担忧的长期后遗症,但人们越来越关注内镜抗反流干预的潜在作用。最后,随着 POEM 的广泛应用,我们继续见证在该程序中规范术后护理和培训的持续努力。POEM 不再是一种新的但已确立的程序。然而,这项技术一直在不断发展,旨在优化治疗成功率,同时降低不良事件和术后反流的风险。

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