Connes Philippe, Nader Elie
Laboratoire Interuniversitaire de Biologie de la Motricité (UR7424), Equipe «Biologie Vasculaire et du Globule Rouge», Université Claude Bernard Lyon 1, Villeurbanne, France.
Br J Haematol. 2024 Oct;205(4):1260-1261. doi: 10.1111/bjh.19704. Epub 2024 Aug 8.
The study of Ellsworth et al. (Br J Haematol, 2024) demonstrated the usefulness of oxygen gradient ektacytometry technique to better identify the physiological parameters that could increase the risk of sickling of red blood cells (RBCs) from sickle cell trait (SCT) carriers. Oxygen gradient ektacytometry combined with pH and osmolality modulations could help in identifying SCT carriers at risk for kidney disorders or exercise-related complications. Other factors than the percentages of haemoglobin S are probably involved in the propensity of RBCs from SCT carriers to sickle during deoxygenation. Commentary on: Ellsworth et al. Hypertonicity and/or acidosis induce marked rheological changes under hypoxic conditions in sickle trait red blood cells. Br J Haematol 2024; 205:1565-1569.
埃尔斯沃思等人（《英国血液学杂志》，2024年）的研究表明，氧梯度血细胞变形性测定技术有助于更好地识别可能增加镰状细胞性状（SCT）携带者红细胞（RBC）镰变风险的生理参数。氧梯度血细胞变形性测定与pH值和渗透压调节相结合，有助于识别有肾脏疾病或运动相关并发症风险的SCT携带者。除血红蛋白S百分比外，其他因素可能也参与了SCT携带者的红细胞在脱氧过程中镰变的倾向。评论：埃尔斯沃思等人。高渗和/或酸中毒在低氧条件下会导致镰状细胞性状红细胞发生显著的流变学变化。《英国血液学杂志》2024年；205:1565 - 1569。
