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在镰状细胞性状红细胞的缺氧条件下，高渗和/或酸中毒会引发显著的流变学变化。

Hypertonicity and/or acidosis induce marked rheological changes under hypoxic conditions in sickle trait red blood cells.

作者信息

Ellsworth Patrick, Pawlinski Izabela J, Sielaty Rachel, Ilich Anton, Prokopenko Yuriy, Moonla Chatphatai, Monroe Dougald M, Pawlinski Rafal, Key Nigel S

机构信息

UNC Blood Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Division of Hematology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

出版信息

Br J Haematol. 2024 Oct;205(4):1565-1569. doi: 10.1111/bjh.19669. Epub 2024 Jul 25.

DOI:10.1111/bjh.19669
PMID:39054759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11486580/
Abstract

Deformability and sickling of red blood cells (RBCs) from individuals with sickle cell trait (SCT) was evaluated under harsh biophysical conditions that mimic certain vascular beds in vivo. RBC deformability in osmotic-gradient ektacytometry was decreased in HbAS (SCT) compared to HbAA (wild-type) RBCs at supraphysiological osmolalities. RBC deformability was also measured by oxygen-gradient ektacytometry. Whereas RBC sickling was not observed under isotonic and neutral pH conditions, hypertonicity and acidosis alone or in combination induced reversible sickling of SCT RBC. These data suggest that hyperosmolality and/or acidosis enhance hypoxia-induced sickling of SCT RBC.

摘要

在模拟体内某些血管床的苛刻生物物理条件下，对镰状细胞性状（SCT）个体的红细胞（RBC）的可变形性和镰变进行了评估。在超生理渗透压下，与HbAA（野生型）RBC相比，HbAS（SCT）的红细胞在渗透梯度血细胞变形性测量中的可变形性降低。还通过氧梯度血细胞变形性测量法测量了红细胞的可变形性。在等渗和中性pH条件下未观察到红细胞镰变，而高渗和酸中毒单独或联合诱导了SCT红细胞的可逆镰变。这些数据表明，高渗和/或酸中毒会增强缺氧诱导的SCT红细胞镰变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4543/11486580/f72fee289abb/nihms-2010282-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4543/11486580/cf1bef183272/nihms-2010282-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4543/11486580/f72fee289abb/nihms-2010282-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4543/11486580/cf1bef183272/nihms-2010282-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4543/11486580/f72fee289abb/nihms-2010282-f0002.jpg

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