Lin He, Chen Haiyan, Wang Jiehui, Ma Xiangai
Department of Operating Room, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
BMC Pediatr. 2024 Aug 8;24(1):510. doi: 10.1186/s12887-024-04989-4.
We aimed to develop and validate a nomogram for predicting the risk of intraoperatively acquired pressure injuries (IAPIs) in children undergoing cardiac surgery with cardiopulmonary bypass (CPB).
This study retrospectively included 208 children aged 21 days to 8 years who underwent cardiac surgery with CPB in a tertiary hospital in China between January 2020 and October 2023. All patients' data were collected from the hospital's medical record system and randomly divided into the training (n = 146) and validation (n = 62) cohorts by a ratio of 7:3. Logistic regression analysis was conducted in the training cohort to identify independent risk factors and establish the nomogram. Finally, calibration curves, receiver operating characteristic (ROC) curves, and decision curve analysis (DCA) were performed in both cohorts to validate the predictive ability of the nomogram.
43 (14.7%) children developed IAPIs. Multivariate analysis showed that low Braden Q scores, use of steroids, skin abnormalities, and low intraoperative SpO were independent risk factors for IAPIs. A nomogram integrating the 4 factors was established. The areas under the curve (AUCs) of the nomogram were 0.836 and 0.903 in the training and validation cohorts, respectively. Furthermore, calibration curves and DCA demonstrated good calibration and clinical applicability of the nomogram.
We constructed a reliable nomogram based on specific risk factors for children undergoing cardiac surgery with CPB, which could be used as an effective and convenient tool for prevention of IAPIs.
我们旨在开发并验证一种列线图,用于预测接受体外循环(CPB)心脏手术的儿童术中获得性压力性损伤(IAPI)的风险。
本研究回顾性纳入了2020年1月至2023年10月在中国一家三级医院接受CPB心脏手术的208名年龄在21天至8岁之间的儿童。所有患者的数据均从医院病历系统中收集,并按7:3的比例随机分为训练队列(n = 146)和验证队列(n = 62)。在训练队列中进行逻辑回归分析,以确定独立危险因素并建立列线图。最后,在两个队列中进行校准曲线、受试者工作特征(ROC)曲线和决策曲线分析(DCA),以验证列线图的预测能力。
43名(14.7%)儿童发生了IAPI。多变量分析显示,低Braden Q评分、使用类固醇、皮肤异常和术中低SpO是IAPI的独立危险因素。建立了整合这4个因素的列线图。列线图在训练队列和验证队列中的曲线下面积(AUC)分别为0.836和0.903。此外,校准曲线和DCA显示列线图具有良好的校准和临床适用性。
我们基于接受CPB心脏手术儿童的特定危险因素构建了一个可靠的列线图,可作为预防IAPI的有效且便捷的工具。