Department of Cardiology, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde, Foshan, Foshan, 528308, P. R. China.
Department of Gynecology, Shunde Hospital, Southern Medical University, The First People's Hospital of Shunde, Foshan, Foshan, 528308, P. R. China.
BMC Womens Health. 2024 Aug 8;24(1):447. doi: 10.1186/s12905-024-03287-6.
The link between insulin resistance and endometriosis is not well established. The triglyceride-glucose (TyG) index serves as a straightforward and economical indicator of insulin resistance. This study examines the link between the TyG index and the prevalence of endometriosis in a U.S.
This cross-sectional study analyzed data from the NHANES conducted between 1999 and 2006. Reproductive health was assessed through questionnaires, and the TyG index was derived from fasting triglyceride and glucose measurements. Weighted logistic regression models were used to analyze the relationship between the TyG index and endometriosis. Restricted cubic spline (RCS) curves explored the linear relationship, while stratified and sensitivity analyses assessed potential interactions and the robustness of the findings.
The study included 2,346 women, with 176 diagnosed with endometriosis and 2,170 without. Women with endometriosis exhibited an elevated TyG index compared to those without the condition. The weighted logistic regression analysis revealed that the TyG index is an independent risk factor for endometriosis (OR = 1.58, 95% CI 1.17-2.14, p = 0.004). RCS analysis indicated a significant positive linear association between the TyG index and endometriosis, with a turning point at 8.51. Subgroup analysis indicated a stronger association in certain populations. The post-propensity score matching analysis confirmed the robustness of these findings.
In the U.S. population, a higher TyG index is positively and linearly associated with endometriosis prevalence. Effective management of blood glucose and lipid levels may reduce the prevalence of endometriosis.
胰岛素抵抗与子宫内膜异位症之间的联系尚未得到充分证实。三酰甘油-葡萄糖（TyG）指数是一种简单、经济的胰岛素抵抗指标。本研究在美国人群中探讨 TyG 指数与子宫内膜异位症患病率之间的关系。
本横断面研究分析了 1999 年至 2006 年期间进行的 NHANES 数据。通过问卷调查评估生殖健康状况，TyG 指数由空腹甘油三酯和葡萄糖测量值得出。使用加权逻辑回归模型分析 TyG 指数与子宫内膜异位症之间的关系。限制性三次样条（RCS）曲线探索线性关系，而分层和敏感性分析评估潜在的相互作用和研究结果的稳健性。
本研究纳入了 2346 名女性，其中 176 名被诊断为子宫内膜异位症，2170 名没有。患有子宫内膜异位症的女性 TyG 指数高于无该疾病的女性。加权逻辑回归分析显示，TyG 指数是子宫内膜异位症的独立危险因素（OR=1.58，95%CI 1.17-2.14，p=0.004）。RCS 分析表明 TyG 指数与子宫内膜异位症之间存在显著的正线性关联，转折点为 8.51。亚组分析表明在某些人群中关联更强。倾向评分匹配后分析证实了这些发现的稳健性。
在美国人群中，较高的 TyG 指数与子宫内膜异位症患病率呈正相关且呈线性关系。有效管理血糖和血脂水平可能会降低子宫内膜异位症的患病率。
