甘油三酯-葡萄糖指数及其相关参数与虚弱的关系。

Association of the triglyceride-glucose index and its related parameters with frailty.

机构信息

The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Department of Geriatric Endocrinology and Metabolism, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning, Guangxi, 530021, China.

出版信息

Lipids Health Dis. 2024 May 21;23(1):150. doi: 10.1186/s12944-024-02147-4.

DOI:10.1186/s12944-024-02147-4

PMID:38773587

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11107008/

Abstract

BACKGROUND

Frailty is a dynamic geriatric condition. Limited studies have examined the association of the triglyceride-glucose (TyG) index and its related indicators [TyG index, triglyceride glucose-waist to height ratio (TyG-WHtR), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-body mass index (TyG-BMI)] with frailty, and the potential links among them remain unclear. On the basis of data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the potential relationships of the TyG index and its related indices with frailty.

METHODS

This research included 7,965 participants from NHANES 2003-2018. The relationship of the TyG index and its related indices with frailty was investigated with binary logistic regression analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve. Potential influences were further investigated through stratified analyses and interaction tests.

RESULTS

The prevalence of frailty in the participants of this study was 25.59%, with a average frailty index of 0.16 (0.00). In the three regression analysis models, the continuous TyG index and its associated indices were positively associated with frailty. In addition, quartiles of TyG, TyG-WC, TyG-WHtR, and TyG-BMI were significantly associated with increased frailty prevalence in the fully adjusted models (TyG Q4 vs. Q1, OR = 1.58, 95% CI: 1.19, 2.09, P = 0.002; TyG-WC Q4 vs. Q1, OR = 2.40, 95% CI: 1.90, 3.04, P < 0.001; TyG-WHtR Q4 vs. Q1, OR = 2.26, 95% CI: 1.82, 2.81, P < 0.001; TyG- BMI Q4 vs. Q1, OR = 2.16, 95% CI: 1.76, 2.64, P < 0.001). According to RCS analysis, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were linearly and positively associated with frailty. ROC curves revealed that TyG-WHtR (AUC: 0.654) had greater diagnostic value for frailty than TyG (AUC: 0.604), TyG-BMI (AUC: 0.621), and TyG-WC (AUC: 0.629). All of the stratified analyses and interaction tests showed similar results.

CONCLUSIONS

Elevated TyG and its associaed indices are associated with an increased prevalence of frailty. Reasonable control of blood glucose and blood lipids, and avoidance of obesity, may aid in reducing the occurrence of frailty in middle-aged and older adults.

摘要

背景

衰弱是一种动态的老年病症。有限的研究考察了甘油三酯-葡萄糖（TyG）指数及其相关指标[TyG 指数、甘油三酯葡萄糖-腰围身高比（TyG-WHtR）、甘油三酯葡萄糖-腰围（TyG-WC）和甘油三酯葡萄糖-体重指数（TyG-BMI）]与衰弱之间的关系，其潜在联系仍不清楚。本研究基于国家健康和营养检查调查（NHANES）的数据，调查了 TyG 指数及其相关指标与衰弱之间的潜在关系。

方法

本研究纳入了来自 2003-2018 年 NHANES 的 7965 名参与者。使用二元逻辑回归分析、限制性立方样条（RCS）和受试者工作特征（ROC）曲线研究 TyG 指数及其相关指标与衰弱之间的关系。通过分层分析和交互检验进一步探讨潜在影响。

结果

本研究参与者中衰弱的患病率为 25.59%，平均衰弱指数为 0.16（0.00）。在三个回归分析模型中，连续 TyG 指数及其相关指标与衰弱呈正相关。此外，TyG、TyG-WC、TyG-WHtR 和 TyG-BMI 的四分位数在完全调整模型中与衰弱患病率的增加显著相关（TyG Q4 与 Q1 相比，OR=1.58，95%CI：1.19，2.09，P=0.002；TyG-WC Q4 与 Q1 相比，OR=2.40，95%CI：1.90，3.04，P<0.001；TyG-WHtR Q4 与 Q1 相比，OR=2.26，95%CI：1.82，2.81，P<0.001；TyG-BMI Q4 与 Q1 相比，OR=2.16，95%CI：1.76，2.64，P<0.001）。根据 RCS 分析，TyG、TyG-WC、TyG-WHtR 和 TyG-BMI 与衰弱呈线性正相关。ROC 曲线显示，TyG-WHtR（AUC：0.654）对衰弱的诊断价值大于 TyG（AUC：0.604）、TyG-BMI（AUC：0.621）和 TyG-WC（AUC：0.629）。所有的分层分析和交互检验都得出了类似的结果。