School of Medicine, West Virginia University, Morgantown, USA.
School of Medicine, University of Florida, Gainesville, USA.
Expert Rev Neurother. 2024 Oct;24(10):953-961. doi: 10.1080/14737175.2024.2385952. Epub 2024 Aug 8.
Chronic Traumatic Encephalopathy (CTE) is a neurodegenerative disorder associated with repetitive head trauma. Historically, the diagnosis has been primarily clinical, which has hindered definitive early diagnosis and proactive intervention.
The authors analyze the recent advancements in early diagnosis of CTE by examining biomarkers, imaging, and clinical decision tools. They discuss the identification of neuropathologies - such as tau aggregates - through novel techniques ranging from blood sampling and to brain density scanning. The reader will walk away with a better understanding of current advancements in early detection and be better equipped to deal with encephalopathies secondary to trauma in clinical practice.
Tremendous progress has been made in understanding the pathophysiology of CTE. Despite these advancements, CTE treatment is still primarily symptomatic rather than underlying disease. Future research should focus on integrating current understanding of CTE pathophysiology with treatment modalities.
慢性创伤性脑病（CTE）是一种与反复头部创伤相关的神经退行性疾病。从历史上看，该疾病的诊断主要依赖临床，这阻碍了明确的早期诊断和主动干预。
作者通过检查生物标志物、影像学和临床决策工具，分析了 CTE 的早期诊断的最新进展。他们讨论了通过从血液采样到脑密度扫描等新技术来识别神经病理学，如 tau 聚集物。读者将更好地了解早期检测方面的最新进展，并在临床实践中更好地应对继发于创伤的脑病。
在理解 CTE 的病理生理学方面已经取得了巨大的进展。尽管有这些进展，但 CTE 的治疗仍然主要是对症治疗，而不是针对根本疾病。未来的研究应侧重于将 CTE 病理生理学的现有理解与治疗方式相结合。
