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尾状核中的神经元多样性:骆驼与人类大脑的比较研究。

Neuronal diversity in the caudate nucleus: A comparative study between camel and human brains.

作者信息

Almasaad Juman M, Bataineh Ziad M, Zaqout Sami

机构信息

Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia.

King Abdullah International Medical Research Centre (KIAMRC), King Abdulaziz Medical City, Jeddah, Saudi Arabia.

出版信息

Anat Rec (Hoboken). 2025 May;308(5):1410-1424. doi: 10.1002/ar.25555. Epub 2024 Aug 8.

DOI:10.1002/ar.25555
PMID:39118384
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11967514/
Abstract

Caudate nucleus (CN) neurons in camels and humans were examined using modified Golgi impregnation methods. Neurons were classified based on soma morphology, dendritic characteristics, and spine distribution. Three primary neuron types were identified in both species: rich-spiny (Type I), sparsely-spiny (Type II), and aspiny (Type III), each comprising subtypes with specific features. Comparative analysis revealed significant differences in soma size, dendritic morphology, and spine distribution between camels and humans. The study contributes to our understanding of structural diversity in CN neurons and provides insights into evolutionary neural adaptations.

摘要

采用改良的高尔基染色法对骆驼和人类的尾状核(CN)神经元进行了研究。根据神经元的胞体形态、树突特征和棘突分布对其进行分类。在这两个物种中均识别出三种主要的神经元类型:多棘型(I型)、少棘型(II型)和无棘型(III型),每种类型又包含具有特定特征的亚型。比较分析显示,骆驼和人类在胞体大小、树突形态和棘突分布方面存在显著差异。该研究有助于我们理解CN神经元的结构多样性,并为进化神经适应性提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/a5017d31d755/AR-308-1410-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/7e7d1826138a/AR-308-1410-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/88f981483ab1/AR-308-1410-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/934e224266fd/AR-308-1410-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/a5017d31d755/AR-308-1410-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/7e7d1826138a/AR-308-1410-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/88f981483ab1/AR-308-1410-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/934e224266fd/AR-308-1410-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d03e/11967514/a5017d31d755/AR-308-1410-g001.jpg

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1
Neuronal diversity in the caudate nucleus: A comparative study between camel and human brains.尾状核中的神经元多样性:骆驼与人类大脑的比较研究。
Anat Rec (Hoboken). 2025 May;308(5):1410-1424. doi: 10.1002/ar.25555. Epub 2024 Aug 8.
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本文引用的文献

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Neural cell diversity in the light of single-cell transcriptomics.单细胞转录组学视角下的神经细胞多样性。
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Neuronal Cell Types in the Spinal Trigeminal Nucleus of the Camel Brain.骆驼脑脊髓三叉神经核中的神经元细胞类型
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A Golgi study of neurons in the camel cerebellum (Camelus dromedarius).骆驼小脑神经元的高尔基研究(Camelus dromedarius)。
Anat Rec (Hoboken). 2022 May;305(5):1264-1276. doi: 10.1002/ar.24742. Epub 2021 Aug 23.
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.单细胞 RNA 测序揭示亨廷顿病突变导致纹状体细胞特征的失调。
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A Golgi study of the camel cuneate nucleus.对骆驼楔束核的高尔基研究。
Anat Rec (Hoboken). 2012 Dec;295(12):2191-204. doi: 10.1002/ar.22570. Epub 2012 Aug 29.
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The nerve cells of the neostriatum in the common shrew (Sorex araneus) and bank vole (Clethrionomys glareolus): a Golgi comparative study.普通鼩鼱(Sorex araneus)和棕背䶄(Clethrionomys glareolus)新纹状体的神经细胞:高尔基染色比较研究
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