State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No.14, Section 3rd of Renmin South Road, Chengdu, 610041, China.
Regen Med. 2024 May 3;19(5):257-278. doi: 10.1080/17460751.2024.2343555. Epub 2024 May 22.
Bioactive ceramics, primarily consisting of bioactive glasses, glass-ceramics, calcium orthophosphate ceramics, calcium silicate ceramics and calcium carbonate ceramics, have received great attention in the past decades given their biocompatible nature and excellent bioactivity in stimulating cell proliferation, differentiation and tissue regeneration. Recent studies have tried to combine bioactive ceramics with bioactive ions, polymers, bioactive proteins and other chemicals to improve their mechanical and biological properties, thus rendering them more valid in tissue engineering scaffolds. This review presents the beneficial properties and potential applications of bioactive ceramic-based materials in dentistry, particularly in the repair and regeneration of dental hard tissue, pulp-dentin complex, periodontal tissue and bone tissue. Moreover, greater insights into the mechanisms of bioactive ceramics and the development of ceramic-based materials are provided.
生物活性陶瓷，主要包括生物活性玻璃、玻璃陶瓷、正磷酸钙陶瓷、硅酸钙陶瓷和碳酸钙陶瓷，由于其生物相容性和刺激细胞增殖、分化和组织再生的优异生物活性，在过去几十年中受到了极大关注。最近的研究试图将生物活性陶瓷与生物活性离子、聚合物、生物活性蛋白和其他化学物质结合起来，以提高其机械和生物学性能，从而使它们在组织工程支架中更有效。本综述介绍了基于生物活性陶瓷的材料在牙科中的有益特性和潜在应用，特别是在修复和再生牙科硬组织、牙髓-牙本质复合体、牙周组织和骨组织方面的应用。此外，还提供了对生物活性陶瓷机制和陶瓷基材料发展的更深入了解。
