Metal-free introduction of primary sulfonamide into electron-rich aromatics.

We report herein a direct and practical synthesis of arylsulfonamides from electron-rich aromatic compounds by using generated -sulfonylamine as the active electrophile. Substrates include derivatives of aniline, indole, pyrrole, furan, styrene and so on. The reaction proceeds under mild conditions and tolerates many sensitive functional groups such as alkyne, acetate, the trifluoromethoxy group or acetoxymethyl ester. Applications of this method for the construction of metal ion sensors and fluorogenic dye have been demonstrated, thus highlighting the potential of this method for probe development.