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本文引用的文献

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Efficacy and safety of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma: pooled analyses after long-term follow-up in KEYNOTE-012.帕博利珠单抗治疗复发性/转移性头颈部鳞状细胞癌的疗效和安全性：KEYNOTE-012 长期随访后的汇总分析。
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Bile duct obstruction in a patient treated with nivolumab as second-line chemotherapy for advanced non-small-cell lung cancer: a case report.纳武利尤单抗二线化疗治疗晚期非小细胞肺癌后发生胆管梗阻：病例报告。
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Imaging and clinicopathological features of nivolumab-related cholangitis in patients with non-small cell lung cancer.尼伏单抗相关胆管炎在非小细胞肺癌患者的影像学和临床病理特征。
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Nivolumab-induced cholangitic liver disease: a novel form of serious liver injury.纳武单抗诱导的胆管炎肝病：一种新型严重肝损伤形式。
Ann Oncol. 2017 Mar 1;28(3):671-672. doi: 10.1093/annonc/mdw649.
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Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.纳武利尤单抗用于复发性头颈部鳞状细胞癌
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一例口腔癌术后肺转移患者发生的胆管炎，作为纳武单抗诱导的免疫相关不良事件

A Case of Cholangitis as a Nivolumab-Induced Immune-Related Adverse Event in a Patient with Pulmonary Metastasis After Surgery for Oral Cancer.

作者信息

Fukuzawa Satoshi, Yamagata Kenji, Uchida Fumihiko, Endo Masato, Sakamoto Noriaki, Bukawa Hiroki

机构信息

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575 Japan.

Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

出版信息

J Maxillofac Oral Surg. 2024 Aug;23(4):979-983. doi: 10.1007/s12663-023-01976-7. Epub 2023 Jul 26.

DOI:10.1007/s12663-023-01976-7
PMID:39118937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11303653/
Abstract

We report a case of cholangitis, an immune-related adverse event (irAE), caused by the administration of nivolumab in a patient with lung metastasis of oral cancer. A 72-year-old man developed pulmonary metastasis after surgery for oral cancer. Hepatic enzyme abnormalities were observed after the second session of treatment, and irAE cholangitis was diagnosed based on the results of the blood test results and endoscopy findings. We suggested steroid treatment, but the patient refused it. Therefore, he was treated with ursodeoxycholic acid. The cholangitis gradually deteriorated, the patients' general condition worsened, and he died 169 days after the onset of cholangitis.

摘要

我们报告了一例由纳武单抗给药引起的胆管炎病例，这是一种免疫相关不良事件（irAE），发生在一名患有口腔癌肺转移的患者身上。一名72岁男性在口腔癌手术后发生了肺转移。在第二次治疗后观察到肝酶异常，并根据血液检查结果和内镜检查结果诊断为irAE胆管炎。我们建议进行类固醇治疗，但患者拒绝了。因此，他接受了熊去氧胆酸治疗。胆管炎逐渐恶化，患者的一般状况变差，在胆管炎发作169天后死亡。