Department of Neurology West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Department of Propaedeutics of Internal Diseases West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Oxid Med Cell Longev. 2024 Aug 1;2024:2121733. doi: 10.1155/2024/2121733. eCollection 2024.
Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins. Occludin, identified as a linchpin in regulating BBB integrity, proves to be a pivotal player, with implications extending to the diagnosis of hemorrhagic transformation in ischemic stroke. This study identifies occludin as a potential biomarker, offering promise for early diagnosis and paving the way for novel diagnostic strategies. The analysis highlights the necessity for a more comprehensive exploration of tight junction proteins, including occludin and claudin-5, particularly in the context of acute cerebral ischemia. The unique healthcare landscape in Kazakhstan adds urgency to the call for further scientific research in this region, emphasizing the need for tailored investigations to address specific regional challenges. This comprehensive overview not only delineates the current state of occludin research but also signals the direction for future investigations. The identified knowledge gaps and emerging trends provide a roadmap for researchers and policymakers alike, with implications for both scientific discourse and clinical practice. Moving forward, a deeper understanding of tight junction proteins, informed by the insights gleaned from this study, holds the potential to shape targeted therapeutic interventions and diagnostic strategies, ultimately contributing to advancements in global stroke care.
在过去的十年中，人们对紧密连接蛋白在与缺血性中风相关的血脑屏障 (BBB) 损伤中的复杂作用进行了大量研究。本文献计量分析探讨了紧密连接蛋白之一紧密连接蛋白 occludin 在 2000 年至 2023 年期间的研究领域，揭示了该关键领域中风发病机制的全球科学贡献、合作和新兴趋势。中国和美国是重要的贡献者，突显了它们在推进我们对紧密连接蛋白的理解方面的突出地位。occludin 被确定为调节 BBB 完整性的关键蛋白，是一个关键参与者，其影响延伸到缺血性中风出血性转化的诊断。这项研究确定 occludin 是一种潜在的生物标志物，为早期诊断提供了希望，并为新的诊断策略铺平了道路。分析强调了需要更全面地探索紧密连接蛋白，包括 occludin 和 claudin-5，特别是在急性脑缺血的情况下。哈萨克斯坦独特的医疗保健景观加剧了该地区进一步科学研究的呼吁，强调需要进行针对性的调查，以解决特定的地区挑战。本综述不仅描绘了 occludin 研究的现状，还为未来的研究指明了方向。确定的知识差距和新兴趋势为研究人员和政策制定者提供了路线图，对科学论述和临床实践都有影响。展望未来，通过这项研究获得的见解深入了解紧密连接蛋白，有可能为有针对性的治疗干预和诊断策略提供信息，最终为全球中风护理的进步做出贡献。
