Tu Bin, Li Yan, Wen Wen, Liu Jian
Department of Ultrasound, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Department of Nephrology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Front Pharmacol. 2024 Jul 25;15:1418142. doi: 10.3389/fphar.2024.1418142. eCollection 2024.
In recent years, with the rapid advancement of fundamental ultrasonography research, the application of ultrasound in disease treatment has progressively increased. An increasing body of research indicates that microbubbles serve not only as contrast agents but also in conjunction with ultrasound, enhancing cavitation effects and facilitating targeted drug delivery, thereby augmenting therapeutic efficacy. The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2023 through bibliometric analysis and to forecast future developmental trajectories.
We selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source. On 19 January 2024, we conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2023 and utilized the bibliometric online analysis platform, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.
Between 1 January 2009, and 31 December 2023, 3,326 publications on ultrasound combined with microbubble therapy technology were included. There were a total of 2,846 articles (85.6%) and 480 reviews (14.4%) from 13,062 scholars in 68 countries/regions published in 782 journals. China and the United States emerged as the primary contributors in this domain. In terms of publication output and global institutional collaboration, the University of Toronto in Canada has made the most significant contribution to this field. Professor Kullervo Hynynen has achieved remarkable accomplishments in this area. is at the core of the publishing of research on ultrasound combined with microbubble therapy technology. Keywords such as "sonodynamic therapy," "oxygen," "loaded microbubbles" and "Alzheimer's disease" indicate emerging trends in the field and hold the potential to evolve into significant areas of future investigation.
This study provides a summary of the key contributions of ultrasound combined with microbubble therapy to the field's development over the past 15 years and delves into the historical underpinnings and contemporary trends of ultrasound combined with microbubble therapy technology, providing valuable guidance for researchers.
近年来，随着基础超声研究的迅速发展，超声在疾病治疗中的应用逐渐增加。越来越多的研究表明，微泡不仅可作为造影剂，还可与超声联合使用，增强空化效应并促进靶向给药，从而提高治疗效果。本研究的目的是通过文献计量分析探索2009年至2023年该领域的现状和主要研究趋势，并预测未来的发展轨迹。
我们选择Web of Science核心合集（WOSCC）中的科学引文索引扩展版（SCI-Expanded）作为主要数据源。2024年1月19日，我们进行了全面检索，涵盖2009年至2023年发表的所有文章和综述，并利用文献计量在线分析平台CiteSpace和VOSviewer软件分析国家/地区、机构、作者、关键词和参考文献，使用Microsoft Excel 2021可视化每年发表文章数量的趋势。
2009年1月1日至2023年12月31日期间，共纳入3326篇关于超声联合微泡治疗技术的出版物。来自68个国家/地区的13062名学者在782种期刊上发表了共计2846篇文章（85.6%）和480篇综述（14.4%）。中国和美国是该领域的主要贡献者。在发表量和全球机构合作方面，加拿大的多伦多大学对该领域贡献最大。库尔勒沃·许宁宁教授在该领域取得了显著成就。 是超声联合微泡治疗技术研究发表的核心。“声动力疗法”、“氧气”、“载药微泡”和“阿尔茨海默病”等关键词表明了该领域的新兴趋势，并有潜力发展成为未来重要的研究领域。
本研究总结了超声联合微泡治疗在过去15年对该领域发展的关键贡献，并深入探讨了超声联合微泡治疗技术的历史基础和当代趋势，为研究人员提供了有价值的指导。
