Boly Timothy J, Lozano-Chinga Michell M, Reyes-Hernandez Melanie E, Elgin Timothy G, Ballas Zuhair, Bermick Jennifer R
Department of Pediatrics, The University of Iowa, Iowa City, IA, USA.
Iowa Inflammation Program, The University of Iowa, Iowa City, IA, USA.
Clin Pediatr (Phila). 2025 Mar;64(3):425-433. doi: 10.1177/00099228241272037. Epub 2024 Aug 9.
Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.
新生儿毛细血管渗漏综合征（CLS）是一种罕见但危及生命的疾病，发生于新生儿败血症或炎性损伤之后。本研究的目的是描述一种标准化的CLS治疗方法，以提高生存率和改善新生儿预后。对10例孕22至26周出生、在遭受重大炎性损伤后发生CLS的婴儿进行了一项回顾性队列研究。记录并描述了两个阶段的诊断时间和治疗方法。在第2阶段，随着对CLS临床认识的提高和标准化治疗方法的实施，治疗时间有非统计学意义的缩短，死亡率显著下降。针对新生儿CLS的早期靶向治疗方法可降低这种高发病的死亡率。
