Huynh Jasmine, Dolan Samantha, Karlin Emily T, Freeman Lisa M, Rozanski Elizabeth A, Rush John E
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
Animals (Basel). 2024 Jul 31;14(15):2218. doi: 10.3390/ani14152218.
Sildenafil is a drug used to successfully manage a variety of cardiopulmonary disorders in people and dogs, but there is limited information on its use in cats. The objective was to review the medical records of cats that received sildenafil as part of their clinical management. Medical records and pharmacy databases were searched for cats that received sildenafil for ≥24 h between 2009 and 2021, and data were collected from medical records. Fifty-five cats received sildenafil for ≥24 h and were included in the study: 43 with primary cardiac disease (acquired, = 28; congenital, = 15) and 12 with primary respiratory disease. Side effects possibly attributed to sildenafil were identified in two cats (systemic hypotension, = 1; polydipsia, = 1), and sildenafil was discontinued in the cat with hypotension. Sildenafil was discontinued in an additional three cats due to a lack of improvement in clinical signs. No cat was documented to develop worsening pulmonary edema within 72 h of starting sildenafil. Median duration of sildenafil administration was 87 days (range, 2-2362 days). Sildenafil administration in cats appeared to be generally well-tolerated. Studies are needed to determine whether sildenafil administration to cats with cardiopulmonary disease improves the quality of life or survival times.
西地那非是一种用于成功治疗人和犬多种心肺疾病的药物，但关于其在猫身上的应用信息有限。目的是回顾接受西地那非作为临床治疗一部分的猫的病历。检索病历和药房数据库，查找2009年至2021年期间接受西地那非治疗≥24小时的猫，并从病历中收集数据。55只猫接受西地那非治疗≥24小时并纳入研究：43只患有原发性心脏病（后天性，=28只；先天性，=15只），12只患有原发性呼吸道疾病。在两只猫中发现了可能归因于西地那非的副作用（全身性低血压，=1只；烦渴，=1只），低血压的猫停用了西地那非。另外三只猫因临床症状无改善而停用西地那非。没有记录显示猫在开始使用西地那非后72小时内出现肺水肿加重。西地那非给药的中位持续时间为87天（范围，2 - 2362天）。猫使用西地那非似乎总体耐受性良好。需要进行研究以确定给患有心肺疾病的猫使用西地那非是否能改善生活质量或延长生存时间。
