Page Allen E, Johnson Mackenzie, Parker Jordan L, Jacob Olivia, Poston Rachel, Adams Amanda A, Adam Emma N
Maxwell H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY 40546, USA.
Animals (Basel). 2024 Aug 2;14(15):2250. doi: 10.3390/ani14152250.
Intra-articular corticosteroids are a popular treatment choice for joint-associated pain and inflammation in horses despite recent work on the metabolic effects of these drugs. The goal of this project was to compare metabolic effects between intra-articular (IA) triamcinolone acetonide (TA) and an autologous protein solution (APS). Five mixed-breed geldings (4-9 years) were utilized for this project. Three identical and consecutive 28-day treatment blocks were used, with metacarpophalangeal IA treatments consisting of equal volumes of saline, a commercially available APS, or 9 mg of TA. Regular plasma and serum samples were collected for ACTH, cortisol, glucose, insulin, and thyroid hormone analysis, in addition to thyrotropin-releasing hormone (TRH) and oral sugar tests (OSTs). Significant treatment effects of IA TA were present at 48 h post-injection in both the TRH and the OST. There was also significant suppression by IA TA of baseline ACTH and cortisol between 2 h and 96 h post-treatment, hyperglycemia between 12 h and 48 h, and hyperinsulinemia at 32 h post-treatment. There were no treatment effects with respect to any measured thyroid hormones, nor were there any significant treatment effects of APS noted. Results suggest at least 2 days and up to 7 days should elapse between a single 9 mg IA TA treatment and OST and/or TRH testing. This study found that TA exhibits significant effects on ACTH, cortisol, glucose, and insulin, while the APS does not.
尽管近期有关于这些药物代谢作用的研究，但关节内注射皮质类固醇仍是治疗马匹关节相关疼痛和炎症的常用方法。本项目的目的是比较关节内注射曲安奈德（TA）和自体蛋白溶液（APS）的代谢作用。本项目使用了5匹4至9岁的混种去势公马。采用了三个相同且连续的28天治疗周期，掌指关节的关节内治疗分别使用等量的生理盐水、市售的APS或9毫克TA。除了促甲状腺激素释放激素（TRH）和口服糖耐量试验（OST）外，还定期采集血浆和血清样本，用于促肾上腺皮质激素（ACTH）、皮质醇、葡萄糖、胰岛素和甲状腺激素分析。关节内注射TA后48小时，TRH和OST均出现显著的治疗效果。关节内注射TA还显著抑制了治疗后2小时至96小时的基础ACTH和皮质醇、12小时至48小时的高血糖以及治疗后32小时的高胰岛素血症。对于任何测量的甲状腺激素均未发现治疗效果，也未观察到APS有任何显著的治疗效果。结果表明，单次9毫克关节内注射TA治疗与OST和/或TRH检测之间应至少间隔2天，最长间隔7天。本研究发现，TA对ACTH、皮质醇、葡萄糖和胰岛素有显著影响，而APS则没有。
