Hirayama H, Kasuya Y, Yagishita A, Katakura T
J Pharmacobiodyn. 1985 Oct;8(10):808-18. doi: 10.1248/bpb1978.8.808.
In an attempt to develop an appropriate infusion program in a continuous subcutaneous insulin infusion system, a conventional pharmacodynamic model (the Bolie model) for describing the relationship between blood glucose and serum insulin levels was evaluated, using a depancreatized dog preparation. The Bolie model was found useful in estimating the basal insulin infusion rate. However, the model could not predict the serum insulin concentration-time profile required to maintain the postprandial blood glucose levels within a physiological range. It will be necessary to develop a more appropriate model for determining the prandial subcutaneous insulin infusion rates in the continuous subcutaneous insulin infusion system.
为了在持续皮下胰岛素输注系统中制定合适的输注方案，使用胰腺切除犬模型评估了一种用于描述血糖与血清胰岛素水平之间关系的传统药效学模型（博利模型）。发现博利模型在估算基础胰岛素输注速率方面有用。然而，该模型无法预测将餐后血糖水平维持在生理范围内所需的血清胰岛素浓度-时间曲线。有必要开发一个更合适的模型来确定持续皮下胰岛素输注系统中餐时皮下胰岛素输注速率。
