中国人群饮食酸负荷与慢性肾脏病的关系：对中国健康与营养调查（2009 年）的综合分析

Association between Dietary Acid Load and Chronic Kidney Disease in the Chinese Population: A Comprehensive Analysis of the China Health and Nutrition Survey (2009).

机构信息

School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Department of Nephrology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China.

出版信息

Nutrients. 2024 Jul 29;16(15):2461. doi: 10.3390/nu16152461.

DOI:10.3390/nu16152461

PMID:39125342

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11314566/

Abstract

BACKGROUND

Dietary acid load (DAL) is closely related to several chronic diseases. However, the link between DAL and chronic kidney disease (CKD) remains scarce and without data from the Chinese populations whose diet is quite different from people in Western countries.

METHODS

This study evaluated DAL by potential renal acid load (PRAL) and net endogenous acid production (NEAP). We clarified the relationship between DAL and CKD by logistic regression analysis based on data from the China Health and Nutrition Survey (CHNS).

RESULTS

The final analysis included 7699 individuals, of whom 811 (11.44%) were CKD patients. Although there was no notable link between PRAL and CKD, higher NEAP levels were independently correlated with CKD. As NEAP values rise, so does CKD prevalence. This trend remains highly significant even after adjustments. In subgroup analyses, the relationship between NEAP and CKD was more consistent in the elderly and subjects with a waistline of less than 82 cm and those without diabetes and heart disease. RCS analysis further confirmed the clear linear relationship between the OR of CKD and NEAP score.

CONCLUSIONS

This study highlighted that higher NEAP was positively correlated with the risk of CKD.

摘要

背景

饮食酸负荷（DAL）与多种慢性疾病密切相关。然而，DAL 与慢性肾脏病（CKD）之间的联系还很少，而且没有来自饮食与西方国家大不相同的中国人群的数据。

方法

本研究通过潜在肾酸负荷（PRAL）和净内源性酸生成（NEAP）来评估 DAL。我们基于中国健康与营养调查（CHNS）的数据，通过逻辑回归分析阐明了 DAL 与 CKD 之间的关系。

结果

最终分析包括 7699 人，其中 811 人（11.44%）为 CKD 患者。虽然 PRAL 与 CKD 之间没有明显的关联，但更高的 NEAP 水平与 CKD 独立相关。随着 NEAP 值的升高，CKD 的患病率也随之升高。即使经过调整，这种趋势仍然非常显著。在亚组分析中，NEAP 与 CKD 之间的关系在老年人以及腰围小于 82 厘米、无糖尿病和心脏病的人群中更为一致。RCS 分析进一步证实了 CKD 和 NEAP 评分之间 OR 的线性关系。