Goldhirsch A
J Steroid Biochem. 1985 Dec;23(6B):1155-60. doi: 10.1016/0022-4731(85)90036-6.
The object of Ludwig III was to assess adjuvant therapy after total mastectomy and axillary clearance in postmenopausal women with breast cancer and axillary node metastases. Chemo-endocrine therapy (cyclophosphamide, methotrexate, 5-fluorouracil, prednisone and tamoxifen: CMFp + T) was compared with endocrine therapy (prednisone and tamoxifen: p + T) and with no adjuvant treatment in 463 evaluable patients aged 65 years or less. Treatment results are available (Ludwig Breast Cancer Study Group, Lancet i (1984) 1256-1260). Nodal status and receptor content of the primary were found to have prognostic value, while tumor size did not.
路德维希三世研究的目的是评估绝经后患有乳腺癌且有腋窝淋巴结转移的女性在全乳切除和腋窝清扫术后的辅助治疗情况。在463名65岁及以下可评估的患者中，对化疗-内分泌治疗（环磷酰胺、甲氨蝶呤、5-氟尿嘧啶、泼尼松和他莫昔芬：CMFp + T）与内分泌治疗（泼尼松和他莫昔芬：p + T）以及不进行辅助治疗进行了比较。治疗结果已公布（路德维希乳腺癌研究组，《柳叶刀》i（1984年）1256 - 1260）。发现原发肿瘤的淋巴结状态和受体含量具有预后价值，而肿瘤大小则不然。
