儿科中枢神经系统肿瘤的生育力保存：来自儿童肿瘤学组的报告。
Fertility preservation in pediatric central nervous system tumors: A report from the Children's Oncology Group.
机构信息
Division of Hematology/Oncology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
出版信息
Pediatr Blood Cancer. 2024 Nov;71(11):e31246. doi: 10.1002/pbc.31246. Epub 2024 Aug 10.
Abstract
The Oncofertility Consortium Pediatric Initiative Network has published recommendations about the risks of infertility due to gonadotoxic therapy. We abstracted gonadotoxic therapies from central nervous system (CNS) Children's Oncology Group (COG) protocols between 2000 and 2022. We assigned them as unknown, minimal, significant, or high levels of increased risk for gonadal dysfunction/infertility. Seven of 11 CNS protocols placed patients at a high level of risk in at least one treatment arm. Males (7/11) were most commonly at a high level of risk, followed by pubertal females (6/11) and prepubertal females (5/11), highlighting the importance of pre-treatment counseling regarding fertility preservation interventions in this population.
摘要
性腺毒性治疗相关不孕风险的安科菲特联盟儿科倡议网络已发布相关建议。我们从 2000 年至 2022 年的儿童肿瘤协作组（COG）中枢神经系统（CNS）方案中提取性腺毒性治疗药物，并将其分为未知、轻度、显著或高度增加性腺功能障碍/不孕风险。11 个 CNS 方案中有 7 个方案至少在一个治疗组中使患者处于高风险水平。男性（7/11）最常处于高风险水平，其次是青春期前女性（6/11）和青春期前女性（5/11），这突出表明在该人群中进行生育力保存干预的治疗前咨询非常重要。
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