Food & Healthcare Group, Wellness Technology Department, Mitsubishi Chemical Corporation, Yokohama-shi, Japan.
Food & Healthcare Group, Wellness Technology Department, Mitsubishi Chemical Corporation, Yokohama-shi, Japan.
Nutrition. 2024 Oct;126:112533. doi: 10.1016/j.nut.2024.112533. Epub 2024 Jul 25.
Heyndrickxia coagulans SANK70258, a representative probiotic, is known for alleviating inflammation caused by cedar pollen, improving the intestinal environment and bowel movements. A previous study on consuming H. coagulans SANK70258 together with galactooligosaccharides showed a trend toward improvement in skin scaliness scores and subjective assessments of skin roughness. However, the effect of H. coagulans SANK70258 alone on the skin remains unclear. Thus, we aimed to re-evaluate the effects of the intake of H. coagulans SANK70258 alone on skin conditions and the intestinal environment through a clinical trial.
This placebo-controlled, double-blind clinical trial involved 80 Japanese women aged 30 to 65 with perceived skin roughness. Participants were divided into placebo and test groups. Over eight weeks, the test group consumed H. coagulans SANK70258, and its effects on skin condition and intestinal health were examined.
The probiotic group showed significant intestinal improvements, with reduced fecal phenol levels (p = 0.044) and pH (p = 0.022), as well as enhanced skin lightness (L* value) (p = 0.040) and liver function tests. Metabolic analyses revealed decreases in fecal Nε-(carboxymethyl)lysine and plasma hydroxyproline, suggesting skin health benefits. There were also significant improvements in skin scaliness (p = 0.015) and bowel movement frequency (p = 0.032) in subgroup analysis.
H. coagulans SANK70258 can improve skin health by improving the intestinal lining. This probiotic reduces the levels of intestinal putrefactive products and advanced glycation end-product levels in feces, suggesting that it may affect not only skin health but also systemic tissues such as the liver.
海氏肠球菌 SANK70258 是一种代表性的益生菌，它可以缓解 cedar 花粉引起的炎症，改善肠道环境和排便。先前的研究表明，同时摄入海氏肠球菌 SANK70258 和半乳糖寡糖可以改善皮肤鳞屑评分和皮肤粗糙度的主观评估。然而，海氏肠球菌 SANK70258 单独使用对皮肤的影响尚不清楚。因此，我们旨在通过临床试验重新评估单独摄入海氏肠球菌 SANK70258 对皮肤状况和肠道环境的影响。
这是一项安慰剂对照、双盲临床试验，涉及 80 名年龄在 30 至 65 岁之间、自觉皮肤粗糙的日本女性。参与者被分为安慰剂组和试验组。在八周的时间里，试验组服用海氏肠球菌 SANK70258，观察其对皮肤状况和肠道健康的影响。
益生菌组的肠道状况明显改善，粪便中酚类物质水平（p = 0.044）和 pH 值（p = 0.022）降低，皮肤亮度（L*值）（p = 0.040）和肝功能试验提高。代谢分析显示粪便中 Nε-（羧甲基）赖氨酸和血浆羟脯氨酸减少，提示皮肤健康状况改善。在亚组分析中，皮肤鳞屑（p = 0.015）和排便频率（p = 0.032）也有显著改善。
海氏肠球菌 SANK70258 通过改善肠道内层来改善皮肤健康。这种益生菌可以降低粪便中肠道腐败产物和晚期糖基化终产物的水平，这表明它不仅可以影响皮肤健康，还可以影响肝脏等全身组织的健康。
