Haque Rezwanul, Alam Khorshed, Gow Jeff, Neville Christine, Keramat Syed Afroz
School of Business, University of Southern Queensland, Toowoomba, Queensland, Australia.
School of Business, University of Southern Queensland, Toowoomba, Queensland, Australia; Centre for Health Research, University of Southern Queensland, Toowoomba, Queensland, Australia.
Value Health. 2025 Apr;28(4):562-570. doi: 10.1016/j.jval.2024.07.022. Epub 2024 Aug 9.
Chronic pain is a highly debilitating condition that affects older adults and has the potential to increase their odds of experiencing cognitive impairment. The primary objective of this study was to examine the correlation between chronic pain and dementia. Additionally, this research endeavors to ascertain whether the association between chronic pain and dementia differs by age and gender.
Cross-sectional data were derived from the Survey of Disability, Ageing, and Carers. A total of 20 671 and 20 081 participants aged 65 years and older in 2015 and 2018, respectively, were included in this study. The pooled association between chronic pain and dementia was assessed using a multivariable logistic regression model. Furthermore, the study also examined the multiplicative interaction effects between chronic pain and age, as well as chronic pain and gender, with dementia.
The pooled analysis demonstrated that chronic pain was associated with a heightened odds of dementia (adjusted odds ratio 1.95; 95% CI 1.85-2.05) among older Australians compared with their counterparts without chronic pain. The interaction effect indicated that individuals with chronic pain across all age groups exhibited increased odds of living with dementia. Additionally, women with chronic pain had higher odds of dementia compared with their counterparts without chronic pain and being male.
A continuous, coordinated, and tailored healthcare strategy is necessary to determine the pain management goals and explore early treatment options for chronic pain in older adults, particularly in groups with the greatest need.
慢性疼痛是一种极具致残性的疾病，影响着老年人，并有可能增加他们出现认知障碍的几率。本研究的主要目的是探讨慢性疼痛与痴呆之间的相关性。此外，本研究还试图确定慢性疼痛与痴呆之间的关联是否因年龄和性别而异。
横断面数据来自残疾、老龄化和护理调查。本研究分别纳入了2015年和2018年的20671名和20081名65岁及以上的参与者。使用多变量逻辑回归模型评估慢性疼痛与痴呆之间的综合关联。此外，该研究还考察了慢性疼痛与年龄以及慢性疼痛与性别之间与痴呆的相乘交互作用。
汇总分析表明，与无慢性疼痛的澳大利亚老年人相比，慢性疼痛与患痴呆症的几率增加有关（调整后的优势比为1.95；95%置信区间为1.85-2.05）。交互作用表明，所有年龄组的慢性疼痛患者患痴呆症的几率均增加。此外，与无慢性疼痛的男性相比，患有慢性疼痛的女性患痴呆症的几率更高。
需要制定一个持续、协调和量身定制的医疗保健策略，以确定疼痛管理目标，并探索针对老年人慢性疼痛的早期治疗方案，特别是针对最有需要的群体。
