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连续脉搏血氧测定术用于肥胖症手术中未确诊阻塞性睡眠呼吸暂停管理的成本效益和安全性:一项全国性队列研究。

Cost-effectiveness and safety of continuous pulse oximetry for management of undiagnosed obstructive sleep apnea in bariatric surgery: a nationwide cohort study.

机构信息

Department of Surgery/Vitalys Clinic, Rijnstate Hospital, Arnhem, The Netherlands.

Department of Public Health, Julius Center Research Program Methodology, University Medical Centre Utrecht, Utrecht, The Netherlands.

出版信息

Surg Obes Relat Dis. 2024 Dec;20(12):1244-1252. doi: 10.1016/j.soard.2024.06.009. Epub 2024 Jul 8.

Abstract

BACKGROUND

Undetected obstructive sleep apnea (OSA) is highly prevalent in patients undergoing bariatric surgery and increases perioperative risks. Screening for OSA using preoperative polygraphy (PG) with subsequent continuous positive airway pressure (CPAP) is costly and time-consuming. Postoperative continuous pulse oximetry (CPOX) is less invasive, and is hypothesized to be a safe and cost-effective alternative.

OBJECTIVES

This nationwide multicenter prospective observational cohort study compared CPOX monitoring with OSA-screening using PG.

SETTING

High-volume bariatric centers.

METHODS

Patients were either postoperatively monitored using CPOX without preoperative OSA-screening, or underwent preoperative PG and CPAP treatment when OSA was diagnosed. Cohort placement was based on local hospital protocols. Cost-effectiveness was analyzed using quality adjusted life years (QALYs) and healthcare costs. Surgical outcomes were also analyzed. Propensity score matching was used in sensitivity analyses.

RESULTS

A total of 1390 patients were included. QALYs were similar between groups at baseline and 1-year postoperatively. Postoperative complications, intensive care unit (ICU)-admissions and admissions, particularly OSA-related, did not differ between groups. Mean costs per patient/year in the CPOX group was €3094 versus €3680 in the PG group; mean difference €-586 (95% CI €-933-€-242). Following propensity score matching, 1090 of 1390 included patients remained, and similar findings for cost-effectiveness, complications, and ICU admissions were observed.

CONCLUSION

CPOX monitoring without preoperative OSA-screening was not associated with higher complication or readmission rates compared to PG. CPOX resulted in lower costs from a healthcare perspective and can therefore be considered a cost-effective alternative to routine OSA-screening in patients undergoing bariatric surgery.

摘要

背景

接受减重手术的患者中,未被发现的阻塞性睡眠呼吸暂停(OSA)患病率很高,且会增加围手术期风险。使用术前多导睡眠图(PG)进行 OSA 筛查,并随后使用持续气道正压通气(CPAP)是一种既昂贵又耗时的方法。术后连续脉搏血氧饱和度监测(CPOX)的侵入性更小,且被假设为一种安全且具有成本效益的替代方法。

目的

本项全国多中心前瞻性观察性队列研究比较了 CPOX 监测与 PG 进行的 OSA 筛查。

设置

大容量减重中心。

方法

患者术后要么使用 CPOX 进行监测,而不进行术前 OSA 筛查,要么在诊断出 OSA 时进行 PG 和 CPAP 治疗。队列的分组基于当地医院的方案。使用质量调整生命年(QALYs)和医疗保健成本来分析成本效益。还分析了手术结果。敏感性分析中使用了倾向评分匹配。

结果

共纳入了 1390 名患者。基线和术后 1 年时,两组的 QALYs 相似。两组患者的术后并发症、重症监护病房(ICU)入住率和入住率,特别是与 OSA 相关的并发症,无显著差异。CPOX 组每位患者/年的平均费用为 3094 欧元,PG 组为 3680 欧元;平均差异为-586 欧元(95%CI-933 欧元至-242 欧元)。在进行倾向评分匹配后,1390 名纳入患者中的 1090 名仍保留在研究中,观察到了类似的成本效益、并发症和 ICU 入住率的结果。

结论

与 PG 相比,不进行术前 OSA 筛查而使用 CPOX 监测不会导致更高的并发症或再入院率。从医疗保健的角度来看,CPOX 可降低成本,因此可被视为接受减重手术患者常规 OSA 筛查的一种具有成本效益的替代方法。

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