N-（5-磷酸核糖基）邻氨基苯甲酸异构酶-吲哚甘油磷酸合酶。1. 一种底物类似物与来自大肠杆菌的双功能酶上的两个不同结合位点结合。 - Suppr

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超能文献

N-(5-Phosphoribosyl)anthranilate isomerase-indoleglycerol-phosphate synthase. 1. A substrate analogue binds to two different binding sites on the bifunctional enzyme from Escherichia coli.

作者信息

Bisswanger H, Kirschner K, Cohn W, Hager V, Hansson E

出版信息

Biochemistry. 1979 Dec 25;18(26):5946-53. doi: 10.1021/bi00593a029.

DOI:10.1021/bi00593a029

PMID:391279

Abstract

摘要

相似文献

N-(5-Phosphoribosyl)anthranilate isomerase-indoleglycerol-phosphate synthase. 1. A substrate analogue binds to two different binding sites on the bifunctional enzyme from Escherichia coli.N-（5-磷酸核糖基）邻氨基苯甲酸异构酶-吲哚甘油磷酸合酶。1. 一种底物类似物与来自大肠杆菌的双功能酶上的两个不同结合位点结合。

Biochemistry. 1979 Dec 25;18(26):5946-53. doi: 10.1021/bi00593a029.

N-(5-Phosphoribosyl)anthranilate isomerase-indoleglycerol-phosphate synthase. 2. Fast-reaction studies show that a fluorescent substrate analogue binds independently to two different sites.N-（5-磷酸核糖基）邻氨基苯甲酸异构酶-吲哚甘油磷酸合酶。2. 快速反应研究表明，一种荧光底物类似物可独立结合到两个不同位点。

Biochemistry. 1979 Dec 25;18(26):5953-9. doi: 10.1021/bi00593a030.

Isolation and characterization of two tryptophan biosynthetic enzymes, indoleglycerol phosphate synthase and phosphoribosyl anthranilate isomerase, from Bacillus subtilis.从枯草芽孢杆菌中分离并鉴定两种色氨酸生物合成酶：吲哚甘油磷酸合酶和磷酸核糖邻氨基苯甲酸异构酶。

J Bacteriol. 1979 Aug;139(2):362-8. doi: 10.1128/jb.139.2.362-368.1979.

Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia coli with engineered monofunctional domains.吲哚甘油磷酸合酶-磷酸核糖基邻氨基苯甲酸异构酶：大肠杆菌双功能酶与工程化单功能结构域的比较

Biochemistry. 1995 Apr 25;34(16):5419-28. doi: 10.1021/bi00016a013.

[Enzymes of the aromatic amino acid biosynthesis in Hansenula henricii: phosphoribosyl-anthranilate isomerase and indole-glycerol-phosphate synthase (E.C.4.1.1.48)].汉氏汉逊酵母中芳香族氨基酸生物合成的酶：磷酸核糖邻氨基苯甲酸异构酶和吲哚甘油磷酸合酶（E.C.4.1.1.48）

Z Allg Mikrobiol. 1978;18(9):629-35. doi: 10.1002/jobm.3630180902.

Phosphoribosylanthranilate isomerase-indoleglycerol-phosphate synthase from Escherichia coli.

Methods Enzymol. 1987;142:386-97. doi: 10.1016/s0076-6879(87)42050-8.

Crystallization and structure solution at 4 A resolution of the recombinant synthase domain of N-(5'-phosphoribosyl)anthranilate isomerase:indole-3-glycerol-phosphate synthase from Escherichia coli complexed to a substrate analogue.

Protein Eng. 1990 Jan;3(3):173-80. doi: 10.1093/protein/3.3.173.

Limited proteolysis of N-(5'-phosphoribosyl)anthranilate isomerase: indoleglycerol phosphate synthase from Escherichia coli yields two different enzymically active, functional domains.N-（5'-磷酸核糖基）邻氨基苯甲酸异构酶（来自大肠杆菌的吲哚甘油磷酸合酶）的有限蛋白水解产生两个不同的具有酶活性的功能结构域。

J Mol Biol. 1980 Nov 15;143(4):395-409. doi: 10.1016/0022-2836(80)90219-3.

Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli.来自大肠杆菌的双功能酶N-（5'-磷酸核糖基）邻氨基苯甲酸异构酶-吲哚-3-甘油磷酸合酶的三维结构

Proc Natl Acad Sci U S A. 1987 Aug;84(16):5690-4. doi: 10.1073/pnas.84.16.5690.

Phosphoribosyl anthranilate isomerase catalyzes a reversible amadori reaction.磷酸核糖邻氨基苯甲酸异构酶催化可逆的阿马多里反应。

Biochemistry. 1995 Apr 25;34(16):5429-39. doi: 10.1021/bi00016a014.

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Investigating the Roles of Active Site Residues in Indole-3-glycerol Phosphate Synthase, a Potential Target for Antitubercular Agents.研究活性位点残基在吲哚-3-甘油磷酸合酶中的作用，该酶是抗结核药物的潜在靶点。

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Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target.结核分枝杆菌色氨酸甘油磷酸合酶：一个潜在的新药物靶点。

Chembiochem. 2022 Jan 19;23(2):e202100314. doi: 10.1002/cbic.202100314. Epub 2021 Sep 20.

Extremely stable indole-3-glycerol-phosphate synthase from hyperthermophilic archaeon Pyrococcus furiosus.来自嗜热古菌激烈火球菌的极其稳定的吲哚-3-甘油磷酸合酶。

Extremophiles. 2019 Jan;23(1):69-77. doi: 10.1007/s00792-018-1061-4. Epub 2018 Sep 27.

Establishing wild-type levels of catalytic activity on natural and artificial (beta alpha)8-barrel protein scaffolds.在天然和人工（β-α）8桶蛋白支架上建立野生型催化活性水平。

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3704-9. doi: 10.1073/pnas.0810342106. Epub 2009 Feb 23.

Kinetic and inhibition studies on substrate channelling in the bifunctional enzyme catalysing C-terminal amidation.对催化C端酰胺化的双功能酶中底物通道化的动力学及抑制研究。

Biochem J. 1999 Jul 1;341 ( Pt 1)(Pt 1):33-40.

Mutational analysis of the active site of indoleglycerol phosphate synthase from Escherichia coli.大肠杆菌磷酸吲哚甘油合酶活性位点的突变分析。

Protein Sci. 1998 May;7(5):1221-32. doi: 10.1002/pro.5560070518.

Phosphoribosyl anthranilate isomerase from Thermotoga maritima is an extremely stable and active homodimer.来自嗜热栖热菌的磷酸核糖邻氨基苯甲酸异构酶是一种极其稳定且活性高的同型二聚体。

Protein Sci. 1996 Oct;5(10):2000-8. doi: 10.1002/pro.5560051006.

Proc Natl Acad Sci U S A. 1987 Aug;84(16):5690-4. doi: 10.1073/pnas.84.16.5690.

The importance of surface loops for stabilizing an eightfold beta alpha barrel protein.表面环对稳定八重β-α桶状蛋白的重要性。

Protein Sci. 1992 Jan;1(1):31-45. doi: 10.1002/pro.5560010105.

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