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砷中毒导致的感音神经性听力损失:一例报告。

Arsenic Poisoning-Induced Sensorineural Hearing Loss: A Case Report.

机构信息

Jining Medical College, School of Clinical Medicine,Jining,China.

Department of Emergency, Affiliated Hospital of Jining Medical College, Jining, China.

出版信息

J Int Adv Otol. 2024 Mar;20(2):182-185. doi: 10.5152/iao.2024.231201.

DOI:10.5152/iao.2024.231201
PMID:39128108
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11114162/
Abstract

Arsenic is frequently used in alternative medicine, and it is critical to promptly identify and treat suspected arsenic toxicity in patients. In a case study, a female patient presented with several symptoms, including nausea, vomiting, bilateral tinnitus, hearing loss, vertigo, and other associated complaints. After admission, the patient showed lethargy, and topical application of Chinese herbal medicine was found on her left breast, along with visible pigmentation on her torso. Examination revealed severe bilateral sensorineural deafness, liver and kidney injury, and pancytopenia. Due to the presence of broken skin, toxicological analysis detected elevated levels of arsenic in both blood (113 ng/mL) and urine (865.4 ng/mL). The patient was diagnosed with arsenic poisoning and received symptomatic treatment, including detoxification. Unfortunately, the patient died due to long-term exposure to arsenic. Therefore, early identification of the etiology is crucial for managing cases of arsenic poisoning.

摘要

砷在替代医学中经常被使用,因此及时识别和治疗疑似砷中毒患者至关重要。在一项病例研究中,一名女性患者出现了多种症状,包括恶心、呕吐、双侧耳鸣、听力损失、眩晕和其他相关的不适。入院后,该患者表现出嗜睡,在其左乳房上发现了中草药的局部应用,同时在其躯干上可以看到明显的色素沉着。检查显示严重的双侧感觉神经性耳聋、肝肾功能损伤和全血细胞减少。由于皮肤破损,毒理学分析检测到血液(113ng/mL)和尿液(865.4ng/mL)中砷含量升高。该患者被诊断为砷中毒,并接受了对症治疗,包括解毒。不幸的是,由于长期接触砷,该患者死亡。因此,早期识别病因对于砷中毒的治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/5e9852a95cce/jiao-20-2-182_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/d96c3b6b7a24/jiao-20-2-182_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/a363f69ac663/jiao-20-2-182_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/5e9852a95cce/jiao-20-2-182_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/d96c3b6b7a24/jiao-20-2-182_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/a363f69ac663/jiao-20-2-182_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf1/11114162/5e9852a95cce/jiao-20-2-182_f003.jpg

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Arsenic intoxication presenting with macrocytosis and peripheral neuropathy, without anemia.砷中毒表现为大细胞性贫血及周围神经病变,无贫血症状。 (注:原文中“without anemia”在中文语境下逻辑似乎不太对,根据医学知识推测这里可能是想表达“无贫血”,但按照英文准确翻译过来是“砷中毒表现为大细胞性贫血及周围神经病变,没有贫血”,译文根据推测进行了调整。)
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