Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Daffodil Smart City, Birulia, Savar, Dhaka 1216, Bangladesh.
Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
Phytomedicine. 2024 Oct;133:155936. doi: 10.1016/j.phymed.2024.155936. Epub 2024 Aug 4.
The global epidemic of Sickle cell anemia (SCA) is causing thousands of children to die. SCA, a genetic disorder affecting the hemoglobin-globin chain, affects millions globally. The primary physiological issue in these patients is the polymerization of sickle hemoglobin within their red blood cells (RBCs) during their deoxygenating state. The RBC undergoes a sickle shape due to the polymerization of mutant hemoglobin within it and membrane deformation during anoxic conditions. To prevent complications, it is essential to effectively stop the sickling of RBCs of the patients. Various medications have been studied for treating SCA patients, focusing on antisickling, γ-globulin induction, and antiplatelet action. Natural and synthetic anti-sickling agents can potentially reduce patient clinical morbidity. Numerous clinical trials focused on using natural remedies for the symptomatic therapy of SCA. Medicinal plants and phytochemical agents have antisickling properties. Recent studies on plant extracts' natural compounds have primarily focused on in vitro RBCs sickling studies, with limited data on in vivo studies. This review discussed the potential role of phytoconstituents in the management of SCA.
全球镰状细胞贫血症（SCA）的流行导致数千名儿童死亡。SCA 是一种影响血红蛋白-球蛋白链的遗传性疾病，影响着全球数百万人。这些患者的主要生理问题是脱氧状态下其红细胞（RBC）中的异常血红蛋白聚合。由于异常血红蛋白在 RBC 内聚合以及缺氧条件下的膜变形，RBC 会呈现镰状。为了预防并发症，有效阻止患者 RBC 镰变至关重要。已经研究了各种药物来治疗 SCA 患者，这些药物主要侧重于抗镰变、γ-球蛋白诱导和抗血小板作用。天然和合成的抗镰变剂可能会降低患者的临床发病率。许多临床试验都集中在使用天然药物治疗 SCA 的症状上。药用植物和植物化学物质具有抗镰变特性。最近对植物提取物天然化合物的研究主要集中在体外 RBC 镰变研究上，体内研究的数据有限。本综述讨论了植物成分在 SCA 管理中的潜在作用。
