Banerjee Bubun, Sharma Aditi, Singh Arvind, Kaur Manmeet, Priya Anu
Department of Chemistry, Akal University, Talwandi Sabo, Bathinda, Punjab, 151302, India.
Curr Top Med Chem. 2025;25(1):96-123. doi: 10.2174/0115680266311332240722065652.
Isatin or 1H-indole-2,3-dione skeleton has been playing a significant role in drug design and development. Isatin itself and many of its derivatives are widely distributed in naturally occurring bioactive compounds. Various synthetic isatin derivatives were found to possess a broad range of significant pharmacological efficacies especially anti-cancer activity against a wide variety of cancer cell lines. Interestingly, on a few occasions, some isatin-derived scaffolds were reported as more potent than the tested reputed drug molecules. As a result, isatin-derived compounds have been gaining significant attention in cancer-based drug developments. In this review, we have summarized literature reported during the last two decades related to the synthesis of structurally diverse isatin-derived scaffolds with promising anti-cancer activities.
异吲哚酮或1H-吲哚-2,3-二酮骨架在药物设计与开发中一直发挥着重要作用。异吲哚酮本身及其许多衍生物广泛分布于天然存在的生物活性化合物中。已发现各种合成异吲哚酮衍生物具有广泛的显著药理功效，尤其是对多种癌细胞系的抗癌活性。有趣的是，在一些情况下，一些异吲哚酮衍生的支架被报道比经过测试的知名药物分子更有效。因此，异吲哚酮衍生的化合物在基于癌症的药物开发中受到了极大关注。在本综述中，我们总结了过去二十年中报道的与具有潜在抗癌活性的结构多样的异吲哚酮衍生支架的合成相关的文献。
