Seroprevalence of immunoglobulins and its association with systemic lupus erythematosus: A systematic review and meta-analysis.

BACKGROUND

The exact cause of systemic lupus erythematosus (SLE) is still unknown. However, hormonal, genetic, and environmental factors may play significant roles in its development. Infection has been recognized as a crucial trigger for SLE development. Several studies have reported a higher prevalence of infections in patients with SLE than in healthy individuals. However, these results were inconsistent. Therefore, this study aimed to conduct a systematic review and meta-analysis of published studies to provide a definitive conclusion regarding the relationship between infection and SLE.

MATERIALS AND METHODS

We conducted a comprehensive search across diverse databases using an array of search tools to uncover pertinent literature. Following the stringent application of the inclusion and exclusion criteria, we carefully selected the appropriate reports for our meta-analysis. Using Comprehensive Meta-Analysis software v4, we analyzed the data and determined the prevalence of antibodies against in patients affected with SLE. To investigate the correlation between seropositivity and SLE, we computed the risk ratios (RRs) and 95% confidence intervals (CI).

RESULTS

Eleven studies were considered eligible for inclusion in the present study. The prevalence of anti-IgG and IgM antibodies against was 33.9% and 7.7%, respectively. A significant association between IgG seropositivity and SLE was observed when compared to the controls (risk ratio = 2.14, 95% CI = 1.42 to 3.22, = .000). However, IgM seropositivity against was comparable between patients with SLE and healthy controls.

CONCLUSIONS

In summary, this study suggests that IgG is more prevalent in patients with SLE than in healthy individuals in areas where infections are more frequent. However, an exact cause-and-effect relationship still needs to be established. Therefore, additional research is necessary to validate these findings and to investigate the underlying mechanisms.