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伊朗普通人群中抗弓形虫 IgG 的血清流行率:2000-2023 年的系统评价和荟萃分析。

Anti-Toxoplasma gondii IgG seroprevalence in the general population in Iran: A systematic review and meta-analysis, 2000-2023.

机构信息

Faculty of Medical Sciences, Department of Laboratory Sciences and Microbiology, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.

Health Research Institute, Infectious Diseases and Tropical Medicine Research Centre, Babol University of Medical Sciences, Babol, Iran.

出版信息

PLoS One. 2024 Aug 29;19(8):e0307941. doi: 10.1371/journal.pone.0307941. eCollection 2024.

Abstract

Toxoplasmosis ranks among the most prevalent parasitic diseases globally. It seems that chronic toxoplasmosis is associated with several neuropsychiatric and other harmful effects in infected people, therefore, there is a need to investigate the prevalence of toxoplasmosis across various world regions. In this study, we conducted a meticulous meta-analysis to estimate the seroprevalence of anti-Toxoplasma gondii IgG antibodies within the general population in Iran (GPI). International and national scientific databases for studies published between January 1, 2000, and September 30, 2023, were searched. Observational studies reporting anti-T. gondii IgG seroprevalence in the GPI was selected/included. The data were synthesized using a random-effects model to calculate with a 95% confidence interval (95% CI) the national and regional anti-T. gondii IgG seroprevalence rates in Iran. Additionally, subgroup analyses were conducted to investigate the frequency of exposition to T. gondii in different socio-demographic, climatic, and geographical scenarios. From 18661 identified studies, 327 were included in the present meta-analysis, encompassing 122,882 individuals across the 31 Iranian provinces. The pooled nationwide anti-T. gondii IgG seroprevalence among the GPI was determined to be 32.9% (95% CI: 30.9-35.1%). The highest anti-T. gondii IgG seroprevalence was observed in Mazandaran province (North of Iran) (61%), whereas the lowest was in Semnan province (12.5%).Anti-T. gondii IgG seroprevalence demonstrated a higher occurrence in provinces characterized by moderate temperatures of 16-21°C, high relative humidity, and annual precipitation. Additionally, a higher anti-T. gondii IgG seroprevalence was identified among individuals with a habit of consumption of undercooked meat, raw fruits or vegetables, and untreated water. Moreover, those reporting direct contact with cats, possessing a lower level of education, residing in rural areas, being engaged in farming occupations, or playing the role of housewives exhibited higher anti-T. gondii IgG seroprevalence figures.The anti-T. gondii IgG seroprevalence within GPI closely aligns with the estimated worldwide average exposition rates. This underscores the imperative for public health policymakers to prioritize educational efforts regarding toxoplasmosis transmission pathways and its link to harmful effects.

摘要

弓形虫病是全球最普遍的寄生虫病之一。慢性弓形虫病似乎与感染人群中的多种神经精神和其他有害影响有关,因此,有必要调查世界各地的弓形虫病流行情况。在这项研究中,我们进行了一项细致的荟萃分析,以估计伊朗一般人群(GPI)中抗弓形虫 IgG 抗体的血清流行率。我们搜索了国际和国家科学数据库,以获取 2000 年 1 月 1 日至 2023 年 9 月 30 日期间发表的研究。选择/纳入了报告 GPI 中抗 T. gondii IgG 血清流行率的观察性研究。使用随机效应模型合成数据,以计算伊朗全国和地区抗 T. gondii IgG 血清流行率,置信区间为 95%(95%CI)。此外,还进行了亚组分析,以调查不同社会人口统计学、气候和地理情况下接触 T. gondii 的频率。从 18661 项确定的研究中,有 327 项被纳入本荟萃分析,涵盖了伊朗 31 个省份的 122882 人。GPI 全国抗 T. gondii IgG 血清流行率的合并率为 32.9%(95%CI:30.9-35.1%)。在伊朗北部的马赞达兰省(Mazandaran province)观察到最高的抗 T. gondii IgG 血清流行率(61%),而在塞姆南省(Semnan province)则观察到最低的流行率(12.5%)。在温度为 16-21°C、相对湿度和年降水量较高的省份,抗 T. gondii IgG 血清流行率较高。此外,在有食用未煮熟的肉、生水果或蔬菜以及未处理的水的习惯的个体中,抗 T. gondii IgG 血清流行率也较高。此外,那些报告直接接触猫、教育水平较低、居住在农村地区、从事农业职业或担任家庭主妇的个体,其抗 T. gondii IgG 血清流行率也较高。GPI 中的抗 T. gondii IgG 血清流行率与估计的全球平均暴露率密切相关。这凸显了公共卫生政策制定者优先考虑有关弓形虫病传播途径及其与有害影响关联的教育工作的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f47/11361691/b7dcb4d07758/pone.0307941.g001.jpg

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