Garel M C, Blouquit Y, Molko F, Rosa J
Biomedicine. 1979 Nov;30(5):234-40.
Normal red blood cells contain, in addition to the major hemoglobin (Hb A) some minor fractions as Hb A2 and glycosylated hemoglobins: Hb A1a, Hb A1b, Hb A1c. The study of the glycosylated hemoglobins has been greatly stimulated by the observation that their proportion was increased in diabetes mellitus. This paper sums up the more recent knowledge on the structure of the minor fractions, and mainly on Hb A1c. Biosynthesis of these hemoglobins is also considered. Since the glycosylated hemoglobins has raised a great interest, different techniques were designed for its assay: chemical, chromatographic and immunological techniques and isoelectric focusing. In this paper, these different methods are reviewed and compared.
正常红细胞除了含有主要的血红蛋白（Hb A）外，还含有一些次要组分，如Hb A2和糖化血红蛋白：Hb A1a、Hb A1b、Hb A1c。糖化血红蛋白比例在糖尿病患者中升高这一观察结果极大地推动了对糖化血红蛋白的研究。本文总结了关于这些次要组分结构的最新知识，主要是关于Hb A1c的知识。还讨论了这些血红蛋白的生物合成。由于糖化血红蛋白引起了极大关注，人们设计了不同的检测技术：化学、色谱和免疫技术以及等电聚焦。本文对这些不同方法进行了综述和比较。
