• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

离子载体调制磁共振成像造影剂

Ion carrier modulated MRI contrast.

作者信息

Duncan Anna M, Ellis Connor M, Levingston Hannah, Kerckhoffs Aidan, Mózes Ferenc E, Langton Matthew J, Davis Jason J

机构信息

Department of Chemistry, University of Oxford South Parks Road Oxford OX1 3QZ UK

Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Level 0, John Radcliffe Hospital Oxford OX3 9DU UK.

出版信息

Chem Sci. 2024 Jul 18;15(34):13937-41. doi: 10.1039/d3sc03466f.

DOI:10.1039/d3sc03466f
PMID:39129769
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310829/
Abstract

An ion-responsive MRI contrast agent based on a POPC liposomal scaffold is generated that displays a large amplitude relaxivity switch. Entrapment of MR active Gd-DOTA within cholesterol-doped, , membrane rigidified, liposomes dampens the MR response through diminished water exchange across the lipid bilayer. Relaxivity is re-established by integration of ion carriers in the liposome membrane to mediate solvated ion flux.

摘要

基于POPC脂质体支架生成了一种离子响应性MRI造影剂，该造影剂显示出大幅度的弛豫率切换。将具有磁共振活性的钆-二乙三胺五乙酸（Gd-DOTA）包裹在掺有胆固醇且膜刚性化的脂质体内，会通过减少跨脂质双层的水交换来抑制磁共振响应。通过在脂质体膜中整合离子载体以介导溶剂化离子通量来重新建立弛豫率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/09d48f3bb3f6/d3sc03466f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/610621c768b0/d3sc03466f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/dca8ab15a494/d3sc03466f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/5aff69f457eb/d3sc03466f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/57537dafd320/d3sc03466f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/09d48f3bb3f6/d3sc03466f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/610621c768b0/d3sc03466f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/dca8ab15a494/d3sc03466f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/5aff69f457eb/d3sc03466f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/57537dafd320/d3sc03466f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8c/11352191/09d48f3bb3f6/d3sc03466f-f5.jpg

相似文献

1
Ion carrier modulated MRI contrast.离子载体调制磁共振成像造影剂
Chem Sci. 2024 Jul 18;15(34):13937-41. doi: 10.1039/d3sc03466f.
2
T1 relaxivity of core-encapsulated gadolinium liposomal contrast agents--effect of liposome size and internal gadolinium concentration.核心包裹钆脂质体造影剂的T1弛豫率——脂质体大小和内部钆浓度的影响
Acad Radiol. 2008 Oct;15(10):1259-63. doi: 10.1016/j.acra.2008.04.018.
3
Liposomes as carriers of amphiphilic gadolinium chelates: the effect of membrane composition on incorporation efficacy and in vitro relaxivity.脂质体作为两亲性钆螯合物的载体：膜组成对包封效率和体外弛豫率的影响。
Int J Pharm. 2002 Feb 21;233(1-2):131-40. doi: 10.1016/s0378-5173(01)00935-8.
4
New dual mode gadolinium nanoparticle contrast agent for magnetic resonance imaging.新型双模式钆纳米颗粒磁共振成像对比剂。
PLoS One. 2009 Oct 29;4(10):e7628. doi: 10.1371/journal.pone.0007628.
5
Liposomal Gd-DTPA: preparation and characterization of relaxivity.脂质体钆-二乙三胺五乙酸：弛豫率的制备与表征
Radiology. 1989 Apr;171(1):77-80. doi: 10.1148/radiology.171.1.2928549.
6
A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging.一种用于磁共振成像的基于高弛豫率钆（III）-DOTA-二硬脂酰磷脂酰乙醇胺的脂质体造影剂。
Eur J Pharm Biopharm. 2009 Jun;72(2):397-404. doi: 10.1016/j.ejpb.2008.09.017. Epub 2008 Oct 10.
7
Interaction of MRI Contrast Agent [Gd(DOTA)] with Lipid Membranes: A Molecular Dynamics Study.磁共振对比剂[Gd(DOTA)]与脂质膜的相互作用：分子动力学研究。
Inorg Chem. 2024 Jun 17;63(24):10897-10914. doi: 10.1021/acs.inorgchem.4c00972. Epub 2024 May 25.
8
Paramagnetic liposomes as MRI contrast agents: influence of liposomal physicochemical properties on the in vitro relaxivity.顺磁性脂质体作为磁共振成像造影剂：脂质体物理化学性质对体外弛豫率的影响
Magn Reson Imaging. 1999 Jan;17(1):83-9. doi: 10.1016/s0730-725x(98)00141-6.
9
Mechanism and kinetics of the loss of poorly soluble drugs from liposomal carriers studied by a novel flow field-flow fractionation-based drug release-/transfer-assay.新型流场流分离药物释放/传递分析法研究脂质体载体中难溶性药物的损失机制和动力学。
J Control Release. 2016 Jun 28;232:228-37. doi: 10.1016/j.jconrel.2016.04.031. Epub 2016 Apr 23.
10
Relaxivity of liposomal paramagnetic MRI contrast agents.脂质体顺磁性磁共振成像造影剂的弛豫率
MAGMA. 2005 Sep;18(4):186-92. doi: 10.1007/s10334-005-0111-y. Epub 2005 Sep 9.

引用本文的文献

1
Organic functionality in responsive paramagnetic nanostructures.响应性顺磁性纳米结构中的有机官能团。
Front Chem. 2025 Aug 14;13:1605538. doi: 10.3389/fchem.2025.1605538. eCollection 2025.
2
Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.合成跨膜阴离子转运体的医学与非医学应用
Chem Rev. 2025 Sep 10;125(17):8370-8425. doi: 10.1021/acs.chemrev.5c00129. Epub 2025 Jul 7.
3
Chloride Selective, Nonprotonophoric Ion Transport with Macrocyclic Halogen Bonding Anionophores.通过大环卤素键合阴离子载体实现的氯离子选择性、非质子传导性离子传输。

本文引用的文献

1
Responsive Anionophores with AND Logic Multi-Stimuli Activation.具有 AND 逻辑多刺激激活响应的阴离子载体。
Angew Chem Int Ed Engl. 2024 May 27;63(22):e202403314. doi: 10.1002/anie.202403314. Epub 2024 Apr 11.
2
Engineering of stimuli-responsive lipid-bilayer membranes using supramolecular systems.利用超分子系统构建刺激响应性脂质双分子层膜
Nat Rev Chem. 2021 Jan;5(1):46-61. doi: 10.1038/s41570-020-00233-6. Epub 2020 Nov 19.
3
Absorption of Phosphonium Cations and Dications into a Hydrated POPC Phospholipid Bilayer: A Computational Study.
Chemistry. 2025 Aug 1;31(43):e202502033. doi: 10.1002/chem.202502033. Epub 2025 Jun 26.
鏻阳离子和双阳离子在水合POPC磷脂双层中的吸收：一项计算研究。
J Phys Chem B. 2022 Jun 6;126(23):4272-88. doi: 10.1021/acs.jpcb.2c02212.
4
Supramolecular chemistry in lipid bilayer membranes.脂质双分子层膜中的超分子化学。
Chem Sci. 2021 Jul 28;12(34):11252-11274. doi: 10.1039/d1sc03545b. eCollection 2021 Sep 1.
5
Mesoporous Silica Nanoparticles in Bioimaging.生物成像中的介孔二氧化硅纳米颗粒
Materials (Basel). 2020 Aug 27;13(17):3795. doi: 10.3390/ma13173795.
6
Peptidic Monodisperse PEG "Comb" as Multifunctional "Add-On" Module for Imaging-Traceable and Thermo-Responsive Theranostics.肽单分散 PEG“梳状”结构作为多功能“附加”模块用于成像示踪和温敏治疗诊断一体化
Adv Healthc Mater. 2020 Feb;9(3):e1901331. doi: 10.1002/adhm.201901331. Epub 2019 Dec 18.
7
Magnetic Nanoparticles Supporting Bio-responsive / Magnetic Resonance Imaging.支持生物响应/磁共振成像的磁性纳米颗粒
Materials (Basel). 2019 Dec 7;12(24):4096. doi: 10.3390/ma12244096.
8
Nanoparticle-Based Paramagnetic Contrast Agents for Magnetic Resonance Imaging.基于纳米粒子的顺磁对比剂用于磁共振成像。
Contrast Media Mol Imaging. 2019 May 5;2019:1845637. doi: 10.1155/2019/1845637. eCollection 2019.
9
Liposome-based probes for molecular imaging: from basic research to the bedside.基于脂质体的分子成像探针：从基础研究到临床应用。
Nanoscale. 2019 Mar 28;11(13):5822-5838. doi: 10.1039/c9nr00207c.
10
Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.磁共振成像对比剂的化学：当前的挑战与新前沿。
Chem Rev. 2019 Jan 23;119(2):957-1057. doi: 10.1021/acs.chemrev.8b00363. Epub 2018 Oct 16.