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与阿替唑单抗治疗相关的腭咽和双侧声带麻痹:癌症免疫治疗中一种严重且此前未记录的副作用。

Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy.

作者信息

Lorente-Piera Joan, Zufiaurre Natalia Díaz, Fernández-González Secundino, Alcalde Juan

机构信息

Department of Otolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3707-3709. doi: 10.1007/s12070-024-04709-5. Epub 2024 Apr 20.

Abstract

Adverse effects of immunotherapeutic treatments like atezolizumab remain largely unknown due to limited experience. We present a 65-year-old man with sudden dyspnea and other symptoms, implicating immunotherapy. Prompt intervention and suspension were crucial. This study identifies a novel unreported adverse effect-bilateral vocal cord and velopalatine paralysis-associated with atezolizumab use.

摘要

由于经验有限,像阿替利珠单抗这样的免疫治疗的不良反应在很大程度上仍不为人知。我们报告了一名65岁男性,他出现了突发呼吸困难和其他症状,提示与免疫治疗有关。及时干预和停药至关重要。本研究发现了一种新的未报告的不良反应——与使用阿替利珠单抗相关的双侧声带和腭帆麻痹。

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