与阿替唑单抗治疗相关的腭咽和双侧声带麻痹：癌症免疫治疗中一种严重且此前未记录的副作用。
Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy.
作者信息
Lorente-Piera Joan, Zufiaurre Natalia Díaz, Fernández-González Secundino, Alcalde Juan
机构信息
Department of Otolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.
出版信息
Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3707-3709. doi: 10.1007/s12070-024-04709-5. Epub 2024 Apr 20.
Abstract
Adverse effects of immunotherapeutic treatments like atezolizumab remain largely unknown due to limited experience. We present a 65-year-old man with sudden dyspnea and other symptoms, implicating immunotherapy. Prompt intervention and suspension were crucial. This study identifies a novel unreported adverse effect-bilateral vocal cord and velopalatine paralysis-associated with atezolizumab use.
摘要
由于经验有限，像阿替利珠单抗这样的免疫治疗的不良反应在很大程度上仍不为人知。我们报告了一名65岁男性，他出现了突发呼吸困难和其他症状，提示与免疫治疗有关。及时干预和停药至关重要。本研究发现了一种新的未报告的不良反应——与使用阿替利珠单抗相关的双侧声带和腭帆麻痹。
相似文献
1
Velopalatine and Bilateral Vocal Cord Paralysis Associated with Atezolizumab Treatment: A Severe and Previously Undocumented Side Effect in Cancer Immunotherapy.与阿替唑单抗治疗相关的腭咽和双侧声带麻痹：癌症免疫治疗中一种严重且此前未记录的副作用。
Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3707-3709. doi: 10.1007/s12070-024-04709-5. Epub 2024 Apr 20.
2
Posterior Graft Laryngotracheal Reconstruction for Bilateral Vocal Cord Paralysis in a Resource-Limited Setting: Building a Replicable Airway Reconstruction Program in Eldoret, Kenya.资源有限地区双侧声带麻痹的后路移植喉气管重建术：在肯尼亚埃尔多雷特建立可复制的气道重建项目
J Otolaryngol Head Neck Surg. 2025 Jan-Dec;54:19160216251345468. doi: 10.1177/19160216251345468. Epub 2025 Jun 17.
3
Vagal nerve magnetic stimulation for post-traumatic cricopharyngeal achalasia with bilateral vocal cord paralysis: A case report.迷走神经磁刺激治疗创伤后环咽肌失弛缓症伴双侧声带麻痹：一例报告
Medicine (Baltimore). 2025 Jul 25;104(30):e43525. doi: 10.1097/MD.0000000000043525.
4
Vocal fold lateralization by percutaneous suture in children: A systematic review.经皮缝合术用于儿童声带外移：一项系统评价
Am J Otolaryngol. 2025 May-Jun;46(3):104606. doi: 10.1016/j.amjoto.2025.104606. Epub 2025 Mar 12.
5
A Single Centre's Experience of Non-Iatrogenic Neonatal Bilateral Vocal Cord Paralysis.单中心非医源性新生儿双侧声带麻痹的经验
J Paediatr Child Health. 2025 Jul;61(7):1039-1048. doi: 10.1111/jpc.70070. Epub 2025 Apr 30.
6
Vocal Cord Paralysis in Pediatric Chiari Malformation: A Systematic Review and Meta-analysis.儿童 Chiari 畸形中的声带麻痹：系统评价和荟萃分析。
Otolaryngol Head Neck Surg. 2024 Dec;171(6):1628-1638. doi: 10.1002/ohn.884. Epub 2024 Jul 2.
7
Surgical Treatment Applied to Bilateral Vocal Fold Paralysis in Adults: Systematic Review.手术治疗应用于成人双侧声带麻痹：系统评价
J Voice. 2023 Mar;37(2):289.e1-289.e13. doi: 10.1016/j.jvoice.2020.11.018. Epub 2021 Jan 16.
8
Surgical Interventions for Pediatric Unilateral Vocal Cord Paralysis: A Systematic Review.小儿单侧声带麻痹的手术干预：系统评价。
JAMA Otolaryngol Head Neck Surg. 2015 Jul;141(7):654-60. doi: 10.1001/jamaoto.2015.0680.
9
Specific allergen immunotherapy for the treatment of atopic eczema.特异性变应原免疫疗法治疗特应性皮炎
Cochrane Database Syst Rev. 2016 Feb 12;2(2):CD008774. doi: 10.1002/14651858.CD008774.pub2.
10
Demographics, Management, and Outcomes Associated With Idiopathic Vocal Fold Paralysis: A Systematic Review.特发性声带麻痹的人口统计学、管理及相关结局：一项系统评价
Otolaryngol Head Neck Surg. 2025 Jun;172(6):1856-1865. doi: 10.1002/ohn.1195. Epub 2025 Mar 7.
本文引用的文献
1
Dataset of phase I and II immunotherapy clinical trials used for a meta-analysis to assess the role of biomarkers in treatment outcomes in diverse cancers.用于荟萃分析以评估生物标志物在多种癌症治疗结果中的作用的I期和II期免疫治疗临床试验数据集。
Data Brief. 2023 Oct 16;51:109698. doi: 10.1016/j.dib.2023.109698. eCollection 2023 Dec.
2
Consider Myocarditis When Patients Treated with Immune Checkpoint Inhibitors Present with Ocular Symptoms.当接受免疫检查点抑制剂治疗的患者出现眼部症状时，要考虑心肌炎。
Oncologist. 2022 May 6;27(5):e402-e405. doi: 10.1093/oncolo/oyac033.
3
Bilateral Vocal Cord Paralysis Due to an Immune-related Adverse Event of Nivolumab: A Case Report.免疫相关不良反应导致的双侧声带麻痹：1 例报告。
J Immunother. 2020 Apr;43(3):93-94. doi: 10.1097/CJI.0000000000000310.
4
Bilateral Vocal Cord Paralysis: Pembrolizumab-Induced Delayed-Onset Toxicity in a Patient with Lung Adenocarcinoma.
J Thorac Oncol. 2018 Dec;13(12):e257-e259. doi: 10.1016/j.jtho.2018.08.2032.
5
Dysphonia induced by vascular endothelium growth factor/vascular endothelium growth factor receptor inhibitors.血管内皮生长因子/血管内皮生长因子受体抑制剂所致的发声障碍
Invest New Drugs. 2010 Dec;28(6):884-6. doi: 10.1007/s10637-009-9314-9. Epub 2009 Sep 16.
Zotero 插件