Verma Prankur, Sikka Kapil, Verma Hitesh, Kumar Rakesh, Thakar Alok, Soneja Manish, Singh Vishwajeet
Department of ENT, All India Institute of Medical Sciences, New Delhi, 110029 India.
Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.
Indian J Otolaryngol Head Neck Surg. 2024 Aug;76(4):3189-3195. doi: 10.1007/s12070-024-04643-6. Epub 2024 Mar 29.
Iron is an important micronutrient involved in cell biology through vital reactions. We examined the correlations between iron metabolism parameters and the course of invasive fungal sinusitis. Patients with invasive fungal sinusitis were enrolled. Serum iron and ferritin levels, total iron-binding capacity, and transferrin saturation were measured at the initiation of treatment. Patients were followed for 6 months, and the clinical course was categorised as improvement or worsening/death. A total of 35 patients were enrolled. The average ferritin levels in mucormycosis patients was 944.9 ng/ml, versus 110.7 ng/ml for aspergillosis patients. Iron levels were significantly lower in mucormycosis than in aspergillosis (29.14 µg/dl vs. 68.55 µg/dl). Total iron-binding capacity was significantly different between the two groups (16.76 µg/dl vs. 330.36 µg/dl). After 6 months, improvement, worsening, and death were noted for 18, 8, and 9 patients, respectively. Higher iron levels and lower ferritin levels were linked with improvement. Total iron-binding capacity was significantly higher in improved patients (2314 vs. 151). Iron metabolism parameters play significant roles in the preemptive judgment of the course of fungal sinusitis. Based on these findings, studies on drugs affecting iron metabolism should be conducted.
铁是一种重要的微量营养素，通过关键反应参与细胞生物学过程。我们研究了铁代谢参数与侵袭性真菌性鼻窦炎病程之间的相关性。纳入了侵袭性真菌性鼻窦炎患者。在治疗开始时测量血清铁和铁蛋白水平、总铁结合力和转铁蛋白饱和度。对患者进行了6个月的随访，并将临床病程分为改善或恶化/死亡。共纳入35例患者。毛霉病患者的平均铁蛋白水平为944.9 ng/ml，而曲霉病患者为110.7 ng/ml。毛霉病患者的铁水平显著低于曲霉病患者（29.14 μg/dl对68.55 μg/dl）。两组之间的总铁结合力有显著差异（16.76 μg/dl对330.36 μg/dl）。6个月后，分别有18例、8例和9例患者出现改善、恶化和死亡。较高的铁水平和较低的铁蛋白水平与改善相关。改善患者的总铁结合力显著更高（2314对151）。铁代谢参数在真菌性鼻窦炎病程的前瞻性判断中起重要作用。基于这些发现，应开展影响铁代谢的药物研究。
