Young D B, Broadbent D A
Trans R Soc Trop Med Hyg. 1985;79(5):687-9. doi: 10.1016/0035-9203(85)90193-2.
The effect of varying levels of extracellular protease production on the bacteriophage type of Vibrio cholerae 1621 serotype 01, biotype E1 Tor, has been investigated. It has been shown that the production of high levels of exoprotease can alter the apparent type of the strain by rendering it insensitive to infection by a number of bacteriophages. Prevention of a productive infection appears to be due to altered surface characteristics rather than to specific damage to the bacteriophages. Such altered surface characteristics may be due to auto-digestion. The importance of this observation to epidemiological studies of V. cholerae is noted and discussed.
已对不同水平的细胞外蛋白酶产生对霍乱弧菌1621型01血清型、E1 Tor生物型噬菌体类型的影响进行了研究。结果表明，高水平胞外蛋白酶的产生可使该菌株对多种噬菌体感染不敏感，从而改变菌株的表观类型。生产性感染的预防似乎是由于表面特征改变，而非噬菌体的特异性损伤。这种表面特征的改变可能是由于自身消化。本文指出并讨论了这一观察结果对霍乱弧菌流行病学研究的重要性。
