显微镜下结肠炎患者动脉粥样硬化疾病的患病率。

Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients.

作者信息

Hong Paul, Krawczyk Karolina, Awan Rehmat U, Hasan Raza, Oruganti Poornima, Ding Xianzhong, Wesolowski Michael, Abegunde Ayokunle T

机构信息

Department of Internal Medicine, Loyola University Medical Center, Maywood, Illinois.

Division of Gastroenterology and Nutrition, Loyola University Medical Center, Maywood, Illinois.

出版信息

Gastro Hep Adv. 2023 Jul 17;2(7):971-978. doi: 10.1016/j.gastha.2023.07.002. eCollection 2023.

DOI:10.1016/j.gastha.2023.07.002

PMID:39130767

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11307428/

Abstract

BACKGROUND AND AIMS

The preponderance of microscopic colitis (MC) in females may be associated with postmenopausal increased risk of atherosclerosis. The aim of this study was to describe the prevalence of atherosclerotic diseases in adults with MC.

METHODS

Retrospective observational study of patients with a diagnosis of MC or incomplete MC at our institution from 2008 to 2018. We performed a chart review and extracted data on demographics, comorbidities, medications, diagnosis, imaging, and endoscopy. Data were analyzed descriptively. Logistic regression was used to estimate the unadjusted effects of different variables on MC.

RESULTS

Of 269 patients, 265 had a MC diagnosis; 236 (89.06%) had collagenous colitis or lymphocytic colitis; and 29 (10.94%) were diagnosed with incomplete MC. Majority were female (79.55%), ≥ 65 years (59.11%), and white (88.81%). Majority had the following risk factors for atherosclerosis, smoking (52.04%), hypertension (58.21%), and hyperlipidemia (59.5%). The prevalence of coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease (CVD) was 16.79% (12.32, 21.27), 8.58% (5.23-11.94), and 7.49% (4.33-10.65), respectively. There was no difference in the prevalence of CAD and CVD after adjusting for sex. Females with MC had reduced odds of PAD compared with males.

CONCLUSION

The prevalence of CAD, PAD, and CVD was 16.79%, 8.58%, and 7.49%, respectively. Similar to the general population, smoking, hypertension, and hyperlipidemia are risk factors for atherosclerosis in MC.

摘要

背景与目的

显微镜下结肠炎（MC）在女性中更为常见，这可能与绝经后动脉粥样硬化风险增加有关。本研究旨在描述成年MC患者中动脉粥样硬化性疾病的患病率。

方法

对2008年至2018年在我院诊断为MC或不完全性MC的患者进行回顾性观察研究。我们进行了病历审查，并提取了有关人口统计学、合并症、药物治疗、诊断、影像学和内镜检查的数据。对数据进行描述性分析。采用逻辑回归估计不同变量对MC的未调整影响。

结果

269例患者中，265例诊断为MC；236例（89.06%）为胶原性结肠炎或淋巴细胞性结肠炎；29例（10.94%）诊断为不完全性MC。大多数为女性（79.55%），年龄≥65岁（59.11%），白人（88.81%）。大多数患者有以下动脉粥样硬化危险因素，吸烟（52.04%）、高血压（58.21%）和高脂血症（59.5%）。冠状动脉疾病（CAD）、外周动脉疾病（PAD）和脑血管疾病（CVD）的患病率分别为16.79%（12.32，21.27）、8.58%（5.23 - 11.94）和7.49%（4.33 - 10.65）。调整性别后，CAD和CVD的患病率无差异。与男性相比，患有MC的女性患PAD的几率降低。