Ghumman Haider, Farooq Jeffrey, Alikhani Puya
Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, USA.
Cureus. 2024 Jul 10;16(7):e64236. doi: 10.7759/cureus.64236. eCollection 2024 Jul.
Scleroderma is a complex autoimmune disorder that primarily affects the connective tissue. Its key pathogenesis comprises vascular abnormalities, autoimmunity, and tissue fibrosis. While the exact etiology of the disease is unclear, patients may exhibit a wide array of symptoms. Scleroderma can rarely induce systemic effects that alter normal cervical spine anatomy. The effects on the cervical spine may be mediated through autoimmune phenomena or dystrophic calcinosis along the vertebral column. We discuss a rare case involving a 60-year-old female with a four-month history of scleroderma, who presented with cervical kyphosis, neck pain, impaired ambulation, dysphagia, edema, and reduced range of motion.
硬皮病是一种主要影响结缔组织的复杂自身免疫性疾病。其关键发病机制包括血管异常、自身免疫和组织纤维化。虽然该疾病的确切病因尚不清楚，但患者可能会出现各种各样的症状。硬皮病很少引起改变正常颈椎解剖结构的全身影响。对颈椎的影响可能通过自身免疫现象或沿脊柱的营养不良性钙化介导。我们讨论了一例罕见病例，患者为一名60岁女性，有4个月的硬皮病病史，表现为颈椎后凸、颈部疼痛、行走障碍、吞咽困难、水肿和活动范围减小。
