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应用异种脱细胞真皮基质治疗孤立性牙龈退缩后的附着增加:一项随机临床试验。

Attachment Gain After Applying Xenogeneic Acellular Dermal Matrix in the Management of Isolated Recessions: A Randomized Clinical Trial.

作者信息

Alabed Mohamad, Dayoub Suleiman, Fawaz Mohamad

机构信息

Periodontology, Damascus University, Damascus, SYR.

Dentistry, International University for Science and Technology (IUST), Damascus, SYR.

出版信息

Cureus. 2024 Jul 12;16(7):e64414. doi: 10.7759/cureus.64414. eCollection 2024 Jul.

DOI:10.7759/cureus.64414
PMID:39130896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11317072/
Abstract

Background and objectives Mucogingival plastic surgery is a surgical procedure performed to prevent or correct anatomical, developmental, or traumatic defects. The problem of gingival recession is common in dental practice, causing pain and dentin hypersensitivity for the patient, and remains difficult to treat surgically at the second surgical site used to harvest the connective graft. Many alternatives have been used to replace connective grafts, but none have been as effective. The importance of guided tissue regeneration remains to gain attachment because it means the formation of new periodontal tissue. This study aims to evaluate the attachment gain (AG) obtained after the management of single gingival recessions of Class I and Class II of Miller's classification. Material and methods This study was designed as a clinical randomized trial using a split-mouth technique. The study sample included 15 patients (30 symmetrical gingival recessions). The first group included the coronally advanced flap (CAF) with the connective tissue graft (CTG), and the second group included the CAF with the Xenogeneic Acellular Dermal Matrix (XDM) (Mucoderm®, Botiss Biomaterials, Zossen, Germany). AG was measured at baseline and after six months. Results The results showed that the mean relative attachment level at baseline was 8.333±0.899 in the CTG+CAF group and 8.466±0.833 in the XDM+CAF group. After six months of follow-up, the levels remained 8.333±0.899 in the CTG+CAF group and 8.466±0.833 in the XDM+CAF group, with a significant difference between the study groups after six months. Conclusion The current study concluded that both grafts applied with the coronally advanced flap led to a gain in attachment, with a greater gain in the CTG group.

摘要

背景与目的

黏膜牙龈整形手术是一种用于预防或纠正解剖、发育或创伤性缺陷的外科手术。牙龈退缩问题在牙科临床中很常见,会给患者带来疼痛和牙本质过敏,并且在用于获取结缔组织移植物的第二个手术部位进行手术治疗仍然很困难。已经使用了许多替代方法来取代结缔组织移植物,但没有一种方法同样有效。引导组织再生的重要性在于获得附着,因为这意味着新的牙周组织的形成。本研究旨在评估在处理米勒分类I类和II类单牙龈退缩后获得的附着增加量(AG)。

材料与方法

本研究设计为采用分口技术的临床随机试验。研究样本包括15名患者(30个对称的牙龈退缩)。第一组包括带结缔组织移植物(CTG)的冠向复位瓣(CAF),第二组包括带异种脱细胞真皮基质(XDM)(Mucoderm®,Botiss生物材料公司,德国措森)的CAF。在基线和六个月后测量AG。

结果

结果显示,CTG+CAF组基线时的平均相对附着水平为8.333±0.899,XDM+CAF组为8.466±0.833。随访六个月后,CTG+CAF组的水平仍为8.333±0.899,XDM+CAF组为8.466±0.833,六个月后研究组之间存在显著差异。

结论

本研究得出结论,两种与冠向复位瓣联合应用的移植物均导致附着增加,CTG组增加更多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/d1932f052bd9/cureus-0016-00000064414-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/0a81e037dc77/cureus-0016-00000064414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/7614f31ae4af/cureus-0016-00000064414-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/3310cc8be58e/cureus-0016-00000064414-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/fa56db8a4aec/cureus-0016-00000064414-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/d1932f052bd9/cureus-0016-00000064414-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/0a81e037dc77/cureus-0016-00000064414-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/7614f31ae4af/cureus-0016-00000064414-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/3310cc8be58e/cureus-0016-00000064414-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/fa56db8a4aec/cureus-0016-00000064414-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b7/11317072/d1932f052bd9/cureus-0016-00000064414-i05.jpg

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本文引用的文献

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Comparison of two types of xenogeneic matrices to treat single gingival recessions: A randomized clinical trial.两种异种基质治疗单发性牙龈退缩的比较:一项随机临床试验。
J Periodontol. 2022 May;93(5):709-720. doi: 10.1002/JPER.21-0212. Epub 2021 Nov 15.
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Comparison between a xenogeneic dermal matrix and connective tissue graft for the treatment of multiple adjacent gingival recessions: a randomized controlled clinical trial.
异种真皮基质与结缔组织移植物治疗多个相邻牙龈退缩的比较:一项随机对照临床试验。
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The use of collagen porcine dermal matrix and connective tissue graft with modified coronally advanced tunnel technique in the treatment of multiple adjacent type I gingival recessions: A randomized, controlled clinical trial.采用猪脱细胞真皮基质和改良的冠向推进隧道技术的结缔组织移植治疗多发性相邻型 I 牙龈退缩:一项随机、对照临床试验。
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