Bao Sichen, Xing Zhenqiu, He Shengkai, Hu Xiaowei, Yang Jianjing, Zhou Bingqing
Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zhejiang-US Joint Laboratory for Aging and Neurological Disease Research, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Neurol. 2024 Jul 26;15:1422984. doi: 10.3389/fneur.2024.1422984. eCollection 2024.
Several studies have explored the relationship between intracranial aneurysms and psychiatric disorders; nevertheless, the causal connection remains ambiguous. This study aimed to evaluate the causal link between intracranial aneurysms and specific psychiatric disorders.
A two-sample Mendelian randomization (MR) analysis was conducted utilizing aggregated genome-wide association study (GWAS) data from the International Stroke Genetics Association for Intracranial Aneurysms (IAs), unruptured Intracranial Aneurysm (uIA), and aneurysmal Subarachnoid Hemorrhage (aSAH). Psychiatric disorder data, encompassing Schizophrenia (SCZ), Bipolar Disorder (BD), and Panic Disorder (PD), were sourced from the Psychiatric Genomics Consortium (PGC), while Cognitive Impairment (CI) data, comprising Cognitive Function (CF) and Cognitive Performance (CP), were obtained from IEU OpenGWAS publications. Causal effects were evaluated using inverse variance weighted (IVW), MR-Egger, and weighted median methods, with the robustness of findings assessed via sensitivity analyses employing diverse methodological approaches.
Our MR analysis indicated no discernible causal link between intracranial aneurysm (IA) and an elevated susceptibility to psychiatric disorders. However, among individuals with genetically predisposed unruptured intracranial aneurysms (uIA), there was a modest reduction in the risk of SCZ (IVW odds ratio [OR] = 0.95, 95% confidence interval [CI] 0.92-0.98, = 0.0002). Similarly, IAs also exhibited a moderate reduction in SCZ risk (OR = 0.92, 95% CI 0.86-0.99, = 0.02). Nevertheless, limited evidence was found to support a causal association between intracranial aneurysms and the risk of the other three psychiatric disorders.
Our findings furnish compelling evidence suggesting a causal influence of intracranial aneurysms on psychiatric disorders, specifically, both IAs and uIA exhibit a negative causal association with SCZ.
多项研究探讨了颅内动脉瘤与精神障碍之间的关系；然而，因果联系仍不明确。本研究旨在评估颅内动脉瘤与特定精神障碍之间的因果联系。
利用来自国际颅内动脉瘤卒中遗传学协会的颅内动脉瘤（IA）、未破裂颅内动脉瘤（uIA）和动脉瘤性蛛网膜下腔出血（aSAH）的汇总全基因组关联研究（GWAS）数据进行两样本孟德尔随机化（MR）分析。精神障碍数据，包括精神分裂症（SCZ）、双相情感障碍（BD）和惊恐障碍（PD），来自精神基因组学联盟（PGC），而认知障碍（CI）数据，包括认知功能（CF）和认知表现（CP），则从IEU OpenGWAS出版物中获取。使用逆方差加权（IVW）、MR-Egger和加权中位数方法评估因果效应，并通过采用不同方法的敏感性分析来评估结果的稳健性。
我们的MR分析表明，颅内动脉瘤（IA）与精神障碍易感性增加之间没有明显的因果联系。然而，在具有遗传易感性的未破裂颅内动脉瘤（uIA）患者中，SCZ风险有适度降低（IVW优势比[OR]=0.95，95%置信区间[CI]0.92-0.98，P=0.0002）。同样，IA患者的SCZ风险也有适度降低（OR=0.92，95%CI 0.86-0.99，P=0.02）。然而，支持颅内动脉瘤与其他三种精神障碍风险之间存在因果关联的证据有限。
我们的研究结果提供了有力证据，表明颅内动脉瘤对精神障碍有因果影响，具体而言，IA和uIA均与SCZ呈负因果关联。
