Petrochenkov Egor, Bencini Giulia, Martinino Alessandro, Lian Amy, Olazar Joanna, Akshelyan Stepan, Yoshikawa Kentaro, Di Cocco Pierpaolo, Almario-Alvarez Jorge, Spaggiari Mario, Benedetti Enrico, Tzvetanov Ivo
Division of Transplantation, Department of Surgery, University of Illinois at Chicago, Chicago, IL.
School of Medicine, University of Illinois at Chicago College of Medicine, Chicago, IL.
Transplant Direct. 2024 Aug 8;10(9):e1671. doi: 10.1097/TXD.0000000000001671. eCollection 2024 Sep.
Robotic-assisted kidney transplant (RAKT) has proven to be a successful approach for patients with morbid obesity and more centers are encouraged to apply robotic approach also for deceased donor kidney transplantation. Prolonged cold ischemia time (CIT) is accompanied by delayed graft function (DGF) and early graft loss after traditional open kidney transplant (OKT). This study examines the impact of CIT after robotic kidney transplantation on settings of deceased donation.
We present a single-center retrospective analysis of 115 cases of RAKT and 128 cases of OKT from deceased donors performed from deceased donor from 2009 to July 2022. Cohort was divided in 3 groups based on CIT ("high" CIT > 15 h, n = 43; "medium" CIT 11-15 h, n = 38; "low" CIT< 11 h, n = 40). The subgroup analysis of DGF and CIT was performed.
The median CIT in the cohort was 13.46 (7) h, and overall rate of DGF was 30.6%. The correlation between CIT and DGF was statistically significant ( = 0.008), and DGF negatively correlated with 1-y graft survival ( = 0.04). The rate of DGF was significantly different between the groups ( = 0.05).
Results from our study demonstrate that the effect of CIT on DGF in settings of RAKT follows a similar pattern as in traditional OKT.
机器人辅助肾移植（RAKT）已被证明是治疗病态肥胖患者的一种成功方法，并且鼓励更多中心在尸体供肾移植中也采用机器人技术。在传统的开放性肾移植（OKT）后，长时间的冷缺血时间（CIT）会伴随着移植肾功能延迟恢复（DGF）和早期移植肾丢失。本研究探讨机器人肾移植后CIT对尸体供肾情况的影响。
我们对2009年至2022年7月间进行的115例RAKT和128例尸体供肾OKT进行了单中心回顾性分析。根据CIT将队列分为3组（“高”CIT>15小时，n = 43；“中”CIT 11 - 15小时，n = 38；“低”CIT<11小时，n = 40）。对DGF和CIT进行亚组分析。
队列中的中位CIT为13.46（7）小时，总体DGF发生率为30.6%。CIT与DGF之间的相关性具有统计学意义（P = 0.008），且DGF与1年移植肾存活率呈负相关（P = 0.04）。各组之间的DGF发生率有显著差异（P = 0.05）。
我们的研究结果表明，在RAKT情况下，CIT对DGF的影响与传统OKT相似。
