Alhetheel Abdulkarim F, Alrfaei Bahauddeen M, Mujamammi Ahmed H, Hakami Jenadi A, Alshuhri Abdullah A
Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
King Abdullah International Medical Research Center (KAIMRC), King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Infect Drug Resist. 2024 Aug 7;17:3353-3365. doi: 10.2147/IDR.S454539. eCollection 2024.
Patients who need to be readmitted to the hospital because of complications from infections or require long-term care and rehabilitation face substantial financial hardships. To ensure the safety of patients undergoing surgery, it is crucial to implement measures that prevent wound infections before and after the procedure. Antibacterial wound dressings are essential to prevent infections during surgical procedures. There are various types of antibacterial wound dressings available on the market, such as silver-based dressings, hydrocolloid dressings, polyhexamethylene biguanide, alginate dressings, collagen-based dressings, and iodine-based dressings.
We used each type (standard, knit, fibril, and non-woven) of a commercial brand of oxidized regenerated cellulose (ORC) called Regecel to test bacterial growth. The choice of antibacterial wound dressing depends on the type of wound being treated. Different bacterial strains require specific culture conditions to thrive and grow in laboratory settings. To obtain accurate and reliable results, it is vital to follow the precise culture conditions required for each bacterial strain.
The evaluation of ORC highlighted its potential to inhibit bacterial growth, showing promising results against various bacterial strains and . Different variants of ORC, such as Regecel, have demonstrated impressive capacity to hinder the growth of 32 distinct bacterial strains, with inhibition rates ranging from 40-100%. These bacteria include methicillin-resistant (MRSA), vancomycin-resistant (VRE), and penicillin-resistant .
This study supports the usage and development of ORC (Regecel) as an innovative approach to treating bacterial infections.
因感染并发症需要再次入院治疗或需要长期护理和康复的患者面临着巨大的经济困难。为确保手术患者的安全,在手术前后实施预防伤口感染的措施至关重要。抗菌伤口敷料对于预防手术过程中的感染必不可少。市场上有多种类型的抗菌伤口敷料,如银基敷料、水胶体敷料、聚六亚甲基双胍、藻酸盐敷料、胶原蛋白基敷料和碘基敷料。
我们使用一种名为Regecel的商业化氧化再生纤维素(ORC)的每种类型(标准型、针织型、原纤型和无纺布型)来测试细菌生长。抗菌伤口敷料的选择取决于所治疗伤口的类型。不同的细菌菌株在实验室环境中需要特定的培养条件才能茁壮成长。为了获得准确可靠的结果,遵循每种细菌菌株所需的精确培养条件至关重要。
对ORC的评估突出了其抑制细菌生长的潜力,对各种细菌菌株显示出有前景的结果。不同变体的ORC,如Regecel,已证明具有令人印象深刻的能力来阻碍32种不同细菌菌株的生长,抑制率在40%至100%之间。这些细菌包括耐甲氧西林金黄色葡萄球菌(MRSA)、耐万古霉素肠球菌(VRE)和耐青霉素肺炎链球菌。
本研究支持将ORC(Regecel)作为治疗细菌感染的创新方法的使用和开发。